England team manager Martin Johnson is expected to name a replacement for Simpson-Daniel on Friday.
The visitors scored five first-half tries through Lesley Vainikolo, Mike Tindall, Ryan Lamb, James Simpson-Daniel and Iain Balshaw.
Despite his talent, Simpson-Daniel has been restricted to only 10 England caps following a catalogues of injuries and illness.
"Gloucester is the only professional rugby club I have ever known, " Simpson-Daniel added.
Wasps fell further behind when Gloucester sliced open their midfield defence nine minutes before the break through Simpson-Daniel's try.
Both Simpson-Daniel and Narraway were injured during Gloucester's Heineken Cup defeat by Cardiff Blues at the Millennium Stadium on Sunday.
Harlequins winger David Strettle may have been next in line to replace Simpson-Daniel but he is recovering from a broken metatarsal.
Head coach Dean Ryan also expressed his delight that Simpson-Daniel would be remaining with the club for the next few seasons.
But Gloucester hit back in the second half when Olivier Azam touched down, with Nicky Robinson converting, before James Simpson-Daniel scored.
But a hat-trick from Simpson-Daniel put the visitors out of sight, meaning Sweeney's late try was little consolation for Dai Young's side.
James Simpson-Daniel finished off a good first-half move to score their opening try and then ran 75m to finish off a fine interception.
But England may turn to Simpson-Daniel's Gloucester team-mate Olly Morgan, who could be fast-tracked from outside the England fold into the senior squad.
Simpson-Daniel went close to claiming his second touchdown, before Junior Paramore delivered a scoring pass to Garvey, who dived over in the corner.
Lamb created the next try five minutes later, intercepting a Wallace pass and surging forward before his pass sent Simpson-Daniel rushing through to score.
Gloucester trailed 10-3 until Freddie Burns struck shortly before the break and James Simpson-Daniel went on to claim a hat-trick in the second half.
When Irish wing Delon Armitage was sin-binned for obstruction, Robinson landed his fifth penalty before Gloucester struck with a 70m breakaway try for Simpson-Daniel.
Hipkiss has been demoted to the England Saxons squad which includes the likes of Northampton's rugby league recruit Chris Ashton and Gloucester wing James Simpson-Daniel.
James Hook edged the Ospreys back in front but James Simpson-Daniel cruised over and Chris Paterson converted and added a penalty to wrap up victory.
The hosts led 27-3 at the break courtesy of tries from Lesley Vainikolo and James Simpson-Daniel and 17 points from the boot of Nicky Robinson.
Evans' boot kept Quins in touch but their forwards were struggling and their lack of pace out wide meant Sharples and James Simpson-Daniel were always a threat.
However, Balshaw ran back a poor kick and found acres of space before Simpson-Daniel cruised over for a superb counter-attacking score which Paterson, on for Lamb, converted.
There are a host of players unavailable because of injury, including fly-half Jonny Wilkinson, wing James Simpson-Daniel, flanker Lewis Moody, wing David Strettle and full-back Nick Abendanon.
The injury is a cruel blow to Simpson-Daniel, who has been in decent form this season and was the Guinness Premiership player of the season last year.
Moseley will arrive at the Memorial Stadium having won their last three games and with a team that includes several Gloucester squad players including James Simpson-Daniel's brother Charlie.
But that was as close as the hosts got as flanker Akapusi Qera fed Simpson-Daniel for his second, and a Burns chip then gave the ex-England wing his treble.
The Wales fly-half was at the heart of their best play and found space for Eliota Fuimaono-Sapolu to send Simpson-Daniel over for their opening try, which Robinson duly converted.
But the visitors failed to capitalise and Simpson-Daniel gathered Bath skipper Michael Classens's loose pass before running almost the length of the field to score, with Robinson adding the extra points.
With Lewsey also departing, Ugo Monye - promoted from the second-string Saxons last week to replace the injured James Simpson-Daniel - could start on the left wing against the Pacific Islanders.
Monye, 25, promoted from the second-string England Saxons side after injuries to Simpson-Daniel and Strettle, and the demotion of Leicester's Tom Varndell, has scored five tries in seven matches this season.
The others are Leicester duo Anthony Allen and George Chuter, Wasps pair Joe Worsley and Tim Payne, Gloucester's James Simpson-Daniel and Paul Doran-Jones, Saracens wing David Strettle and Harlequins flanker Chris Robshaw.
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