After two relatively quiet years in the Senate, Mr. Rubio is taking his first significant risk.
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Whistle-blowers undoubtedly face significant risk and must do cost-benefit analysis to decide whether to come forward.
If the force continues to shrink, it can do so only by accepting significant risk.
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This could create significant risk for cloud consumers, which can be mitigated by strong governance.
In truth, Chinese investments to date have not posed any significant risk to U.S. national security.
But there is a significant risk in using Avastin for treatment of lung cancer.
Air power is to be used only when there is no significant risk of civilian deaths.
There is also a significant risk of damage to the heart, which is made of muscle tissue.
And they highlight a "significant risk" from the effect of having an international border in hindering trade.
In a few years, the world will be at significant risk of protectionist policies damaging world trade.
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Findings identified "gaps in service provision", but no children were found to be "at significant risk from harm".
The energy world is changing very quickly, which poses a significant risk for thirty to forty year investments.
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Douglas warns there remains a significant risk that another crash is on the horizon without more significant regulatory control.
The postbankruptcy lenders are first in line during a liquidation, but even so they are taking a significant risk.
It is unclear that this situation really presents a significant risk for bondholders.
Anything less than that and the company may be putting itself at significant risk should oil prices really fly.
"We do not expect a significant risk, " said Chief Financial Officer Jim Muehlbauer.
And its report says there is a 'significant risk' of having more polio cases in 2013 than in 2012.
There is a significant risk that these practices will undermine noble sales purpose.
Caerphilly council said pooling budgets posed a "significant risk" as it could be considered to be subsidising its neighbour's services.
Of course, the latter comes with significant risk that he splits his party and swiftly finds himself out of a job.
There were also problems about the way information about Lloyd was shared and he was not identified as a "significant risk".
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There's a significant risk that High Speed 2 will become the latest in a long series of government big project disasters.
It said it exposed the organisation to a significant risk of fraud.
The procedure still requires general anesthesia, and still has carries significant risk.
Ms O'Neill said such "extra beds" were often "not clinically appropriate" and posed a "significant risk" to patients, their families and to staff.
Yet there remains a significant risk that one or more of the uncertainties which currently worry investors will blossom into a full-scale panic.
When assessing the merits of a generic drug with a unique drug delivery technology, the most significant risk of course is patent protection.
Delivering a termination notice will trigger a series of events that are difficult to unwind or postpone without putting the organization at significant risk.
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From the company's perspective, there is no legal risk to remove the content, yet there is potentially significant risk for failing to do so.
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