Agencies must submit updates when significant changes to the Enterprise Architecture occur.

WHITEHOUSE: CIRCULAR NO. A-130 Revised

And those counties where gun ownership was highest (where an increase in gun carrying could occur) did not see any significant changes in crime when their states passed concealed-weapons laws.

ECONOMIST: Economics focus

When comprehensive lifestyle changes are offered as treatment (not just as prevention), significant cost savings occur in the first year because the biological mechanisms that control our health and well-being are so dynamic.

CNN: Change your lifestyle, reverse your diseases