But Cardiff had faced a significant challenge for this award from Wales' Grand Slam-winning rugby team.
Baraclude - After Plavix, Baraclude is the next significant challenge that BMS will have to face immediately.
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The company faced a significant challenge in competing "in a more crowded, competitive market arena, " he said.
Ghani told CNN the most significant challenge Afghanistan's next president faces is earning back the trust of the people.
Even before the suit, changing the tightly regulated New York taxi market was proving to be a significant challenge.
But no matter how many copies each game sells, these companies face one significant challenge: there can only be one leader.
This is where it tackles a significant challenge: allowing experienced musicians and one-finger wonders alike to "play" it as an instrument.
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There would be no significant challenge that would be gratifying to overcome.
Many agencies are wary of volunteers due to a precieved lack of training, commitment, or professionalism and that can be a significant challenge.
That would have been a significant challenge to retailers, given how many types of phones any store sells and how quickly that inventory changes.
Outbox 's partners hope it will be the most significant challenge Ticketmaster has faced since 1991, when it bought Ticketron, its only major competitor.
As a community, we face a significant challenge in tackling HIV.
"Goodyear competes in a global industry, so cost is a significant challenge, " company spokesman Ed Markey said in an email summarizing key goals in the negotiations.
Energy efficiency is the most significant challenge standing in the way of continued miniaturization of electronic systems, and miniaturization is the principal driver of the semiconductor industry.
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Respondents said that the most significant challenge they face when working with big data is accessing the data siloed in various business applications across the organization (76%).
"Although Zimbabwe is not facing armed conflict, humanitarian threats such as food shortages and outbreak of diseases such as cholera pose a significant challenge, " said Agostinho Zacarias, U.N.
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The most significant challenge will be in sourcing enough new vaccine, as there is only one manufacturer which will have to assess its capacity to deliver enough product.
Any change in supplier or design would be "a pretty significant challenge, " the person said, requiring layers of modification from hardware to controlling software to adjust for a new battery.
Who else is likely to mount a significant challenge?
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That the shipwrecked hero, a young Indian boy named Piscine Molitor Patel -- "Pi" for short -- didn't have another human soul to talk to for 200 days presented another significant challenge.
Valerie Thompson from the E-Learning Foundation, which aims to provide learning technologies to children both at home and at school, said that while will.i.am's donation was "fantastic", there remained "a very significant challenge".
He will not face a significant challenge either from within his own party or from any other party no matter how he comes down on issues like Alon's appointment or the Court's radicalism.
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In 1986, the U.S. Navy had replaced the Royal Navy as Number One Fleet, and badly outgunned the Soviets, but the Soviet Navy still posed a significant challenge to Western dominance of the seas.
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Finally, the combination of multiple channels, markets, and devices highlights the most significant challenge of all: real omni-channel execution and insight in a world of applications that were not built to work together.
This is a significant challenge in the workplace.
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It would not only be confronting a problem that affects huge numbers of women, it would be mounting a significant challenge to a system that will otherwise continue to stand between women and full emancipation.
Another significant challenge arising from the adoption of cloud and mobile platforms is the increasing burden on end users to keep up with all the URLs and passwords they need to remember to do their jobs.
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Mr Edwards said one council for the north east and another for north west Wales could address a "significant financial challenge".
"Restructuring international cricket is a significant strategic challenge and one that must be dealt with, " said Lorgat after a two-day chief executives' committee meeting in Cape Town this week.
Yesterday, Gwynedd council leader Dyfed Edwards said one authority for the north east and another for north west Wales could address the "significant financial challenge" rather than the current six local authorities.
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