Stress was a significant cause of teachers being off sick according to the figures.
Anthropogenic carbon emissions in the atmosphere and oceans are the most significant cause of global climate change.
Pushing the Federal Funds Rate below 3% was probably the most significant cause of The Great Credit Crunch.
The coroner ruled that the drug was the only significant cause of death and recorded a narrative verdict.
Pollution from road traffic, particularly diesel fumes, is the most significant cause of poor air quality in most cities.
Health experts say once unknown bacteria including campylobacter, commonly found in chicken, are now thought to be a significant cause of such disorders as Guillain-Barre Syndrome, which can cause paralysis.
Andrew Husband, principle lecturer in pharmacy at the University of Sunderland and lead on the Gateshead study said allergies were a significant cause of avoidable adverse drug reactions among hospital in-patients each year.
According to the American Psychological Association's 2008 "Stress in America" survey, 80 percent of Americans reported in September that the economy is a significant cause of stress, up from 66 percent in April.
The most significant cause of the increased adoption of the Internet by Europeans is the continuous increase in the penetration of Internet-enabled devices, such as PCs, throughout the region, said Datamonitor in a statement.
So any significant repatriation of those funds would cause a significant depreciation in the Brazilian currency, the real.
Large pieces would survive the re-entry and could cause significant damage upon impact with the Earth.
Your symptoms must cause significant stress or difficulty in social, work or other settings.
That can cause significant impact to end users, and be a costly mistake to the bottom line.
As good as the technology has become, it still has accuracy problems that can cause significant harm.
The challenge is that failure to apply these techniques in advance can cause significant tax and liquidity challenges.
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Even under the best of circumstances, transplants cause significant suffering and disability and they are always life-altering.
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High-volume web scraping could cause significant monetary damages to the sites being scraped.
The obesity indication might be particularly useful as a complement to some schizophrenia drugs, which cause significant weight gain.
However, if the system goes awry, it can cause significant problems for consumers.
That could cause significant collateral damage to many auto dealerships that use LIFO.
"Wholesale removal of U.S. attorneys would cause significant disruption to the work of the Department of Justice, " he wrote.
Certainly replacing 18 bridges in Ealing will cause significant problems for the whole area and those who travel through it.
"Mold exposure does not cause significant disease, " says Paul Wax, a practicing toxicologist in Phoenix who isn't involved in litigation.
Because they are not well absorbed, however, overconsumption of sugar alcohols can cause significant gastrointestinal symptoms including gas, bloating and diarrhea.
"The burglars have been prepared to cause significant damage to the stores in order to get what they wanted, " she said.
That is even though both sides agree the spending cuts as currently spelled out will cause significant fiscal harm to the economy.
In a November survey of nonprofit executives, we found that more than 90% agreed that the federal cuts will cause significant problems.
"If travel is essential, the public should avoid exposed or coastal areas where gusts could cause significant harm to individuals, " he said.
And National Football League salary transparency can cause significant strife among co-workers.
But even one significant loss can cause a big and expensive headache.
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