In that study, Lipitor did not have the muscle side effects seen in this Zocor trial.
Unlike Lopid, it does not seem to make the potential muscle side effects of drugs like Lipitor and Zocor more frequent.
The trial also showed a higher rate of muscle side effects for patients getting the top dose than many cardiologists had expected.
Nissen also points to the muscle side effects as a serious problem.
The new label warned that giving Baycol with Lopid, a Pfizer cholesterol drug, substantially increased the likelihood of potentially dangerous muscle side effects.
The Food and Drug Administration warned in 1999 that combining the cholesterol drugs Baycol and Lopid increased the risk of deadly muscle side effects.
The new label warned that giving Baycol with Lopid, a Pfizer (nyse: PFE - news - people ) cholesterol drug, substantially increased the likelihood of potentially dangerous muscle side effects.
's (nyse: PFE - news - people ) Lipitor or Merck 's (nyse: MRK - news - people ) Zocor cut the odds of heart attack or stroke in high-risk patients by a third, but they also can cause side effects that destroy muscle tissue and, eventually, the liver.
Zetia lacks the muscle-weakening side effects that afflict the current crop of cholesterol blockbusters, called statins.
But right-hander Matt Garza will miss the start of the season with an injured muscle in his side.
That drug combines Zocor with another medicine, Zetia, to lower cholesterol substantially--potentially without the muscle-harming side effects of the statins.
The new label adds a clearer warning regarding the risk of rare muscle-weakening side effects that can lead to kidney damage or death.
Worse, one in 250 patients taking the highest dose of the medicine had serious muscle-weakening side effects, which in rare cases can be lethal.
But Lipitor, Zocor and similar drugs can have muscle-weakening side effects.
One market for the shot will be the 5% or more of patients who cannot take statins like Lipitor or Crestor because of their muscle-damaging side effects.
That's important because, while the statins are generally considered very safe, they have been known to have serious muscle-weakening side effects that can lead to dangerous kidney problems in rare cases.
The optimistic case for Zetia is that adding it to a low dose of a statin will lower cholesterol as much as a high dose of the statin, but without the muscle-weakening side effects.
Chelsea's attacking struggles twice persuaded Terry to desert his defensive post in an attempt to add some muscle to his side's forward line and he was lurking dangerously as a Florent Malouda's cross floated across the six-yard box.
Merck withdrew the 160-milligram top dose of Zocor from consideration at the U.S. Food and Drug Administration, Nissen writes, because of muscle-weakening side effects, which it may have caused more than 5% of the time--data that was not publicized.
Take the case of Baycol, the Bayer (nyse: BAY - news - people ) cholesterol drug that was pulled from the market in August 2001 because it caused potentially deadly muscle and liver side effects, called rhabdomyolysis, more than similar medicines, such as Lipitor and Zocor, do.
In that study, 53 patients on the most potent 80-milligram dose of Zocor developed serious muscle weakness called myopathy, one of the recognized side effects of cholesterol drugs, and seven developed a more serious muscle problem called rhabdomyolysis.
Wright was diagnosed with a moderate strain of the intercostal muscle on his left side Friday, an injury that may have been exacerbated by his presence in the WBC.
He strained a muscle in his left side during his first bullpen session on Feb. 23 last year but recovered in time for opening day, when he allowed three runs in the ninth against Toronto in a game the Blue Jays won in 16 innings.
The problem was an old flag-football knee injury that had caused muscle atrophy on the injured side.
An old flag-football knee injury had hung around too long, which led to muscle atrophy on the injured side.
"You can see the physical effects in her stature, due to loss of muscle and stuff on one side of her body, " he said.
Giffords has good movement and muscle tone on her left side, he said, and some on her right side as well, although not as much as the left.
Researchers at Tufts University, writing in the journal Circulation, found that doctors were significantly more likely to report serious muscle, kidney and liver side effects during Crestor's first year on the market than they were for other cholesterol-lowering drugs, such as Lipitor, Zocor and Pravachol.
Pull off the small white piece of muscle that is attached to the side of the scallops (some might not have it).
Statins are among the safest drugs on the market, but in patients at very low risk of heart attack, their potential muscle- and liver-damaging side effects become more worrisome.
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