They also said the side effects were in line with previously known side effects for the top 80-milligram dose of Zocor.
They look bad for niacin, as the combo caused diabetes and other side effects even in patients who were selected because they could initially take niacin without serious side effects.
Functions controlled by these bacterial genes could therefore be attacked with less risk of side effects in humans.
The idea that the drugs might have such side effects in rare cases was not new.
In that study, Lipitor did not have the muscle side effects seen in this Zocor trial.
Eli Lilly, Abbott and AstraZeneca have run into problems with side effects in developing nicotinic receptor drugs.
Another worry: Clioquinol was pulled from the market decades ago because it caused neurological side effects in Japan.
They are designed to cause less side effects in patients than the more common non-steroidal anti-inflammatory drugs (NSAIDS).
Patients choose new, expensive medications rather than existing, cheaper generics in search of minor reductions in side effects.
The FDA delays a promising set of drugs due to side effects in rodents that may not apply to humans.
She worked hard to take the setbacks and side effects in stride.
Many promising pills fail because of nasty side-effects in a few patients.
One worry about combining the treatments is an increase in side effects, particularly damage to the heart, which is an issue with Herceptin.
Soon after the Elan deal ended, Lilly's chemists made a few tweaks and devised a new secretase blocker that showed fewer side effects in animals.
As with other supplements, just because a product is natural does not mean that it is completely safe and free of side effects in everyone.
Generic drugmaker Ranbaxy Laboratories will make the biggest, 80-milligram dose, which is rarely used because of an increase in side effects with high doses of the drug.
Eli Lilly (nyse: LLY - news - people ), Abbott and AstraZeneca have run into problems with side effects in developing nicotinic receptor drugs.
This drug class, known as the Cox-2 inhibitors, stops inflammation without causing the side effects in the stomach or intestine that can result from older drugs like aspirin and ibuprofen.
But the very clinical studies Glaxo is using as its defense are the ones that Nissen says inspired him to look into Avandia's heart side effects in the first place.
So far officials of the National Institutes of Health say they've seen no serious side effects in clinical trials and that study subjects who have been immunized have generated a good response.
Naurex said the main side effects in a Phase IIa study of its GLYX-13 compound with 116 people with depression were headache and sleepiness, similar to the effects of a placebo saline injection.
In its review, CHMP concluded that dronedarone increases the risk of injury to the liver and the lungs and may increase the risk of cardiovascular side effects in some patients with non-permanent AF.
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The drug does cause side-effects in some patients, including, rarely, cancer of the lining of the womb, but the scientists said that the increased chance of preventing breast cancer returning far outweighed the risk.
Yet they're exposed to anti-convulsants, anti-psychotic drugs, which have serious long-term side effects in the form of obesity, metabolic syndrome, diabetes and some movement disorders ... that can leave a person extremely disfigured physically.
Standardizing the way that risk to patients is measured in studies, so that side effects are always handled in the same way.
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The UK trial - in which all eligible children will receive immunotherapy - will attempt to reduce the severe side effects seen in the US study.
In addition, cost or side effects could play an important role in how the drugs are used in treatment, if they're approved by the U.S. Food and Drug Administration.
Worse, one in 250 patients taking the highest dose of the medicine had serious muscle-weakening side effects, which in rare cases can be lethal.
Dr Stephen Fox, a GP from Leigh in Lancashire became so worried by the level of side effects he was seeing in his elderly patients that he is asked the NHS if there was any research evidence on statins and the over-75s.
In general, side effects of Byetta can include diarrhea, nausea, and vomiting, which may contribute to changes in kidney function, says Dr. Richard Hellman, the past president of the American Association of Clinical Endocrinologists, and a clinical professor at the University of Missouri--Kansas City School of Medicine.
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