Yachvili put his side back into the lead with a penalty after 16 minutes.
Napoli striker Edinson Cavani missed a penalty to get his side back into the game.
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But Ponting and Hodge shared 154 in 24 overs to put their side back into the ascendancy.
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However, Chris Bridge's try and extras nine minutes before the interval pulled the home side back into the game.
Villanova, as an eight seed, was the lowest ever to win it on the men's side back in 1985.
After 25 minutes the visitors forced the home side back when O'Donnell took Shaun Lunt's short pass to crash over.
But tries from centre Eric Artiguste and replacement prop Leonie Tzabatze brought the side back on level terms with Pau.
Benitez's fellow striker Jerome could have scored a hat-trick before he eventually brought his side back into the match on the hour.
Glenn Ferguson had a glorious chance to get the home side back in the game but his header went just over the bar.
Uruguay talisman Luis Suarez dragged his side back into the tie, with a key role in both Gaston Ramirez's equalizer and Nicola Lodeiro's winner.
Connor edged the home side back in front with a penalty, and exchanged three-pointers with Jones to leave the Dragons ahead at the break.
Dons boss Craig Brown had replaced the anonymous Sone Aluko with Magennis at half-time and the Northern Irishman brought his side back into the game.
It is slightly counter-intuitive but nonetheless the change made by Greece coach Fernando Santos was critical in getting his side back into the match.
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Two goals in the first 12 minutes from Marcus Berg had them in control but substitute Itay Shechter pulled the Israeli side back into the game.
Eventually the scores were locked on 26-26 as Wigan captain Andy Farrell missed a chance to edge his side back in front with seven minutes left.
Adams brought the home side back into the match in the 36th over, smashing three fours to bring the run rate to a run a ball.
An entertaining match finished 2-2 after extra time, with Boyd twice hauling his side back into the game after goals from Noel Hunt and Mark de Vries.
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Thomas put his side back in front with a drive over the line which put the Dragons a solitary point ahead at 19-18, but Goosen slotted a third penalty.
Sinfield's short pass on 49 minutes put Myler in for another to edge his side back in front and Sinfield accepted Jamie Peacock's offload to go over three minutes later.
Bishop was brought down just short before the Scarlets managed to kill the ball, conceding a penalty that Connor converted to put the home side back into the lead 9-8.
Captain Kevin Pietersen (63) tried to haul his side back into the match but was run out and the tourists were soon dismissed for 229, a loss by 158 runs.
Paul Hartley tried to haul the home side back into the game, but goalkeeper Graeme Smith beat out his free-kick and dived on the loose ball with several attackers waiting to pounce.
They were transformed to the more secure and positive thinking side back on their Lancashire territory, but had initially found the defensive 4-5-1 formation of a miserly Birmingham difficult to play through.
Gale converted all three tries but Sinfield brought his side back into the game just before the break when he went through a yawning gap in the visitors' defence for a solo try.
Marcato converted the 34th-minute try and brought his side back to within six points of the visitors with a penalty four minutes after the break when the Ospreys were penalised at a scrum.
And it was Drogba who hauled his side back into the game when he exploited the space at right-back, after Pantsil had been forced off injured, and headed in Branislav Ivanovic's far-post cross.
Fletcher put the home side back on top after the break with a left-footed strike from the right-hand side of the penalty area in the 63rd minute after some good work by Nish.
Gidley soon put the home side back in front when he latched on to a neat pass from dummy-half Keiron Cunningham to bundle over from five yards in the corner, converted by Sean Long.
Italy won a penalty for offside two minutes after the break despite the ball being outside the ruck and Bergamasco launched the ball between the posts to put the home side back in front.
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