Wales' last Six Nations visit to Scotland in 2007 ended in a 21-9 defeat, although two years before that Mike Ruddock's side had swept to a 46-22 win on their way to the 2005 Grand Slam.
After reviving their side by putting on 116 in 23 overs, the sixth-pair were swept up by Matt Mason and Jones in a spirited response by Worcestershire's injury-hit attack after tea.
England had five overs to negotiate before lunch and although they did so, Cook's day went from bad to worse soon after the re-start as he swept straight into the hands of the one fielder on the leg side and departed for 21.