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Former world No. 1 Caroline Wozniacki continued her decline, as the Danish 10th seed lost 6-2 6-4 to another Kazakh player, Yaroslava Shvedova.
CNN: Tennis stars Federer and Nadal honor 'a very loved man'
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Polish sixth seed Agnieszka Radwanska defeated former world No. 1 Ana Ivanovic 7-5 7-5 to set up a clash with Kazakhstan's Yaroslava Shvedova.
CNN: Champion Murray battered by Fish in another Miami upset
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No. 27 Yaroslava Shvedova lost to Paula Ormaechea 6-4, 7-6 (6).
NPR: Ex-No. 1 Jankovic Advances At Rainy French Open
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Robson has now lost both her singles matches at the Burswood Dome, but felt she improved on her first-up loss to Yaroslava Shvedova on Monday.
BBC: Laura Robson and Andy Murray
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Safarova didn't leave Charleston empty-handed, however, securing her first WTA doubles title alongside Russia's Anastasia Pavlyuchenkova as they beat Spaniards Anabel Medina Garrigues and Yaroslava Shvedova 5-7 6-4 10-6.
CNN: STORY HIGHLIGHTS
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Lisicki also moved into round two of the singles, coming from behind to beat Tunisian teen Ons Jabeur -- ranked 297th -- and securing a match against Kazakhstan's Yaroslava Shvedova.
CNN: Williams sisters progress in Olympic tennis events
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Third seed Daniel Hantuchova, of Slovakia, gained a 6-2 6-4 victory over Olga Govortsova, of Belarus, while fourth seed Na Li , of China, overcame Russian Yaroslava Shvedova 4-6 6-2 6-0.
BBC: SPORT | Tennis | Cavaday claims second-round spot
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But the 2008 French Open champion, who also beat Azarenka on her way to the semi-finals in Rome in May, fought back to set up a second-round clash with Yaroslava Shvedova.
BBC: Ana Ivanovic beats Victoria Azarenka at Cincinnati Open
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Former world number one Ana Ivanovic , currently down to 62 in the world rankings, beat 32nd seed Yaroslava Shvedova 6-1 7-5, having seen off ninth-seeded Victoria Azarenka in the first round.
BBC: Kim Clijsters through in rain-hit Cincinnati Open