Hull looked nervous and Jobi McAnuff's deflected shot had keeper Boaz Myhill scrambling across his goal.
The striker sold Daniel Agger with the best dummy of the night before placing his shot past keeper Pepe Reina.
His side-foot shot beat keeper Andy Collett but, agonisingly for Boro's 25, 000-strong support, the strike trickled just the wrong side of the far post.
Nicolas Anelka put Chelsea in front with a 22-yard shot but keeper Petr Cech missed a cross and Kieran Richardson lashed in an equaliser.
Distillery's second came when a long ball caught out McDonagh and former Glenavon striker Liggett took advantage to slide his shot under keeper Andrew Plummer.
Hull's defence was again breached when Yakubu found Gosling in acres of space on the right and the midfielder ran on goal before driving a shot past keeper Matt Duke.
Twente striker Bryan Ruiz robbed Sebastien Bassong of possession and, after racing clean though on goal, tried to chip a shot over keeper Heurelho Gomes, who stuck out a vital hand to excellently save.
Florent Malouda chipped a ball into the run of Anelka and the French striker angled in a left-foot shot which keeper Martin Dubravaka failed to get a hand to despite it being within saveable range.
He broke the deadlock in the 59th minute, collecting an infield pass from Zoltan Gera before manoeuvring himself into a shooting position on the edge of the box and curling a superb shot past keeper Diego Benaglio.
Gardner also had a shot saved by keeper Gunnar Sigurdsson and an effort deflected wide from 10 yards.
Healy shot straight at keeper Jan Mucha while Stephen Craigan's timely challenge denied Sestak going clear on goal.
In a fine individual effort, he beat the Algerians' defence and struck a left-footed shot past their keeper.
Briscoe had two strikes on goal and Kyle Nix shot straight at keeper Seb Brown when well placed.
Cliftonville were quick to reply and McMullan shot straight at keeper Aaron Hogg.
Diomansy Kamara put Fulham back into it with 20 minutes left by drilling a shot through 'keeper Joe Hart's legs.
Healy sealed the win when he latched on to a Jones cross and slotted his shot under Potters keeper Thomas Sorenson.
Emnes out-muscled covering Foxes defender Curtis Davies to power a 20-yard shot under visiting keeper Chris Weale in the 49th minute.
The visitors soon found their feet and Jon Daly tested Darren Randolph with a low shot but the keeper was equal to it.
Westwood was finally beaten when a long-diagonal free-kick deep into stoppage time fell to Freedman and the Leeds forward put a close-range shot through the keeper's legs.
But seven minutes later right winger Carney missed a free header, and seconds before the break striker Sanderson shot straight at keeper Christine Nilsen from four yards.
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Reading did threaten when Long headed John Oster's free-kick wide and Matejovsky fired in a bouncing shot that City keeper Joe Hart did well to push away.
The Gulls were looking the hungrier of the two sides, and Lee Mansell was allowed to run unchallenged before firing a long-range shot into the keeper's hands.
Sheringham then found room down the right and picked out Scholes in the area, but Scholes fluffed his shot and the keeper pushed it round his left-hand post.
Things began promisingly enough for Derby when Commons hustled Darron Gibson off the ball and fired in a rasping shot that United keeper Ben Foster was grateful to see fly wide.
His opposite number Brad Friedel had his palms warmed by a solid strike from Osman and the American was beaten from the following corner when Bilyaletdinov snapped a shot past the keeper.
Brede Hangeland nodded a corner wide, Zamora shot straight at keeper Povilas Valincius and Zoltan Gera flashed wide of the near post as the Cottagers failed to turn their increasing dominance into goals.
Hull repelled the first effort from Matt Taylor but the ball found its way to Steinsson and he drove in a low shot which Tigers keeper Boaz Myhill could only help on its way into the net.
Moments later Sordell ran into the box and bent a shot around Pools keeper Jake Kean, and the 19-year-old extended the lead after collecting a Dale Bennett pass and calmly placing a shot in the bottom corner.
The Blues were unperturbed by this early setback and Essien restored equality after 19 minutes when he took a pass from Florent Malouda and fired a swerving shot past Apoel keeper Dionisios Chiotis, who had no chance.
Anelka, not as sharp as he has been in previous seasons, should have scored late in the first half when he was played in by Ramires, but fired his low shot at American keeper Howard, who anticipated well.
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