Derbyshire struggled against Shaun Udal (4-37) and Pedro Collins (4-46), with only Chris Rogers (75) resisting as they were all out for 182.
BBC: Wickets tumble as Middlesex edge into lead
However, Tremlett's fireworks were in vain as Pedro Collins removed Stewart Walters and Tim Linley while Shaun Udal saw off Jade Dernbach to secure a win.
BBC: Tremlett knock in vain as Surrey crash to innings loss
"I think Shaun tried to hurry through the rehab and get up here because he knew we needed help, " manager Terry Collins said.
WSJ: Marcum exits early again, Mets lose to Pirates 7-3
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