Kadcyla will carry a boxed warning, the most severetype, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death.
Still more severe disease will require oral medications that encourage the pancreas to make more insulin such as glyburide or glipizide Some patients with even more severetype 2 disease are treated with subcutaneous injections of insulin.
Here, the literature also points to a positive feedback effect with decisive expenditure-based fiscal consolidation because this type of consolidation appears to foster growth, in particular in times of severe fiscal imbalances.