Hampshire's outgoing chief constable has warned further cuts to budgets could seriously impact police services.
Back in 2009, United Airlines had no idea one poorly handled customer interaction could seriously impact their reputation.
And if you want to (or must) sell, even a small interest rate move can seriously impact your return.
Too many ignore the risk of just a few of trades each year, which can seriously impact the performance of your whole portfolio.
It said internet piracy still had a seriously impact on the industry, estimating that nearly a third of all internet users regularly access unlicensed sites to download music.
It is true of the government's awakening to the potentially seriously negative impact on inward investment of constrained runway capacity in the south east.
It will impact seriously on Woodeaton and all those who live there.
"We will have to seriously evaluate the impact of this hike on our prices, and have no choice other than to pass on the increase to the customer, " he said.
Expert witnesses and police officers may be able to withstand the pressure of their performance being broadcast, he said, but "fearful or intimidated witnesses would refuse to attend court, which could impact seriously if not terminally on the successful prosecution of a case".
"There is a risk that introducing a border will reduce trade, and this would impact much more seriously on the Scottish economy than on the economy of the rest of the UK, " write Swales and McGregor.
So that is in essence holding a gun to the head of the American people because make no mistake, the specific consequences of default may be unknowable or unpredictable, but we know they will be seriously negative and they will impact -- they will have an impact directly on the American people.
The University of Stirling is to look into the impact fulfilling the dreams of seriously ill children has on them and their families.
Robinson also testified that the United States and other G-7 nations were seriously underestimating the scope, duration and impact of the Soviet debt crisis.
The problem may not be the Bank of England's target but whether there are really any appropriate tools available to seriously counteract the pernicious, growth stymying impact of deleveraging, the urge to repay debts.
This question is being taken increasingly seriously by scientists as more is learnt about the impact a near earth object (NEO) would have on the future of civilization.
In light of the economic impact, the importance of the balloon industry must be taken seriously.
"We have to take these comments very seriously, and report it to the higher authorities in regards to potential economic impact, " Mr Turner said.
So every decision is very painful, engages lives, has a huge impact on how people live, whether they live or not, and if you take that responsibility seriously it can be quite heavy.
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