Philippe Senderos came in to the centre, and he has suffered a torrid time.
Abou Diaby put Arsenal into an early lead but Sami Hyypia lost Phillipe Senderos to head an equaliser.
Arsenal's Philippe Senderos, on loan at Everton, is selected after only five appearances for both clubs this season.
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After 17 minutes, Pandiani shrugged off Philippe Senderos and cut the ball back to Stephen Clemence who sidefooted over.
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"Senderos has had only a little match practice at club level, but he has always justified my confidence, " he said.
BBC: World Cup 2010: Teenager Xherdan Shaqiri in Swiss squad
And the 61-year-old former German international also backed Senderos despite his lack of first-team football at the Emirates and Goodison Park.
BBC: World Cup 2010: Teenager Xherdan Shaqiri in Swiss squad
Central defender Phillipe Senderos was heavily criticised earlier in the season after struggling to cope with the physicality of Chelsea's Didier Drogba.
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It was a short-lived let-off, Swiss defender Senderos volleying in the resultant corner from Reyes for his first goal in a Gunners shirt.
But Arsenal failed to find the net and Matthew Etherington stretched the Hammers' lead after Larsson and Phillipe Senderos were caught in possesion in defence.
"I want to go, I want and need to be playing ahead of the World Cup, " said Senderos, who has been capped 33 times by his country.
Moyes tried to sign Senderos last summer but the move is thought to have stalled over Arsenal's valuation of the player, who was also strongly linked with Celtic.
Arsenal had come to Spain hoping to win the group and Wenger entrusted the task to a team includeing Philippe Senderos, Eduardo, Gilberto, Bendtner, Armand Traore and Justin Hoyte.
Eidur Gudjohnsen flicked on to free Drogba, who shrugged off Senderos's tackle and against all the odds remained on his feet after Lehmann and Lauren tried to clear the danger.
McFadden should have doubled the home side's lead in the fifth of nine minutes of stoppage time but allowed Phillippe Senderos to tackle him after finding himself one-on-one with Almunia.
Arsenal continued to dominate before the interval and could have restored their two-goal advantage, Gordon doing well to turn over another powerful Van Persie drive and Senderos heading wastefully wide when unmarked.
The visiting side did have the ball in the net just before the interval when Senderos slid in to convert a deep Leighton Baines free-kick but the defender was penalised for offside.
Martin Albrechtsen's cross from the right was only half-cleared by Senderos at the near post allowing Kanu to pounce and power home a rising volley on 37 minutes against his former employees.
On eight minutes Drogba was quicker to read the flight of Del Horno's pass than Senderos and after controlling the ball on his chest, the Chelsea striker struck a neat volley past Lehmann.
Having sold Philippe Senderos to Fulham and with Gallas and Silvestre believed to have played their last games for the club after their contracts expired, Koscielny will provide Wenger with more defensive depth.
In Group Two, leaders Switzerland took a step closer to automatic qualification with a 3-0 victory in Luxembourg, as defender Philippe Senderos scored twice before Benjamin Huggel also netted in the 22nd minute.
With Johnny Heitinga cup-tied and Sylvain Distin suspended, Everton had a new central defensive partnership in Yobo and Philippe Senderos - and the latter was very harshly penalised for a foul on Yannick Djalo.
But the Gunners were made to pay after half an hour when Senderos was caught flat footed and Hyypia had the freedom of the Anfield penalty box to head past Cesc Fabregas and in off the post.
The Gunners continued to threaten and centre-half Philippe Senderos had a 35-yard shot that flew just over the bar while Walcott failed to hit the target from six yards out as he connected with an Adebayor centre.
He was on hand to awkwardly steer home from close range with his weaker right foot after Eren Derdiyok -- who like Yakin is of Turkish origin -- beat the offside trap to collect a long pass from defender Philippe Senderos.
Cuando era joven caminaba en las sierras de Naolinco, de Chiconquiaco, de Misantla, por senderos propicios llenos de ecos de aves nerviosas y quebranto de ramas, y llegaba a escribir versos de once y de catorce porque es lo que uno hace a esa edad.
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