Approval also would be a triumph for Adams--the second time he has invented a medicine and steered it through development.

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The patent on a new drug starts running out the second the medicine is invented, and it can take many, many years to get these big clinical trials done.

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When nearly 30 years ago Dr. Jacob Fraden invented an ear thermometer working on this second principle, the infrared light sensor was so large that he needed a narrow gold-plated reflective tube to channel the light from the ear drum to the sensor.

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"You can't assume the other person gets it, " says Ms. Hanson, 42, who's now working on a second business that sells a diaper-changing pillow she invented called the SnuggWugg.

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During the second world war at Marconi he was part of the team that invented a radio direction-finder which was fitted to British bombers.

ECONOMIST: Christopher Cockerell

The second company in which I invested, back in 2001, was a novel concept from the serial entrepreneur who invented social networking.

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