The absences forced coach Mick Potter to name rookie debutant Lee Gaskell, 19, at stand-off, with Jon Wilkin back in the side at scrum-half alongside him after a 12-match injury absence.
Three forward drives produced a scrum and the home side unleashed a wave of attacks which eventually saw Barnard just burrow his way over in the corner for a try awarded by the video referee.
Irish then saw substitute Dan Murphy sin-binned for pulling down a scrum with the home side camped just five metres from their line, and Dickinson put them out of their misery when he rumbled over at the death.
France-based Perry Freshwater, who can play on either side of the scrum, has been preferred to Yates as the fourth prop.
Gomarsall, in for the rested Danny Care, had earlier released Monye to dot down unopposed down the side of a scrum while the two front rows were still exchanging blows.
Arlidge replied a minute before the break with his only successful shot at goal, but the Biarritz scrum-half ensured his side were 9-8 ahead at the break with an immediate response.
Scrum-half Boss scored his side's crucial try in the 69th minute, but Nacewa was again off-target with the conversion.
Like many top scrum-halves Dawson has a spiky side to his character, as he freely admits.
The home side managed to avoid a scrum until just before Thomas was due to rejoin the fray.
The home side finally gained dominance in the scrum and were awarded a penalty from the set piece on 55 minutes to make it 15-9.
Parks found space from the scrum, feinting left before targeting the blind-side, but a certain try was blown when his pass went too high for Lome Fa'atau to take cleanly.
Nonetheless, the London side refused to lie down and won a scrum deep inside the Northampton 22.
However, the home side had struggled as pinpoint kicking from Hull scrum-half Adam Dykes set up Hull's three first-half scores.
The home side had not finished, though, and scrum-half Mike Prendergast's try with two minutes to go all but confirmed victory.
But Wasps made the home side pay and broke out from the resulting scrum, ending in Waldouck's try at the other end.
The southern hemisphere side were reduced to 14 men when replacement scrum-half Aaron Smith was sin-binned for cynically killing the ball after a Jordan Turner-Hall break.
Sharks number eight Sebastien Chabal was lucky not to follow Jones to the sin bin when he kicked the ball away after his side were penalised for standing up in the scrum.
They began to play with much more fizz and although Ryan Davis missed a long-range penalty, they got on the scoreboard five minutes after the restart when ex-Springbok scrum-half Claassens sniped over down the blind-side of a ruck.
With Munster restored to their full complement, Eoghan Hickey managed their first points from a penalty but the home side immediately struck back when, from a scrum, Humphreys put Trimble clear though referee Allain Rolland failed to notice a blatant forward pass from Ulster's outside half.
BBC: Paul Steinmetz gave Ulster the perfect start at Ravenhill
Nigel Davies' under-fire side were scrappy in the opening exchanges, teenage scrum-half Gareth Davies looking nervous on his first start as his poor pass put the visitors under pressure.
Tebaldi kicked the hosts in front from an early penalty but missed three more before the scrum-half's try and subsequent conversion put his side 10 points up after 27 minutes.
It was a scintillating start to the match for the Welsh side and, although they suffered a blow as scrum-half Jason Spice went off with a broken arm, they soon took the lead with a quite brilliant try.
Quins fly-half Adrian Jarvis hit the crossbar from 30 metres soon after and the home side injected a bit of life into the game when England scrum-half Shaun Perry made a 25m jinking run.
Richie Pugh takes over from Dafydd Jones at open-side flanker, Ken Owens replaces Rees, Tavis Knoyle is scrum-half instead of Martin Roberts, Rob Higgitt fills Davies' centre spot while Stoddart fills Mark Jones' wing spot.
Mike Phillips is the favourite to start at scrum-half but Blair's ability to make darting breaks around the side of the breakdown will scare the Boks.
Referee Nigel Owens awarded a penalty try after replacement Kings scrum-half Josh Fowles illegally came round to disrupt it on the Lions side, and O'Gara's conversion made it 20-3.
Paul O'Connell provided the beef to widen a half-break by his backs, allowing scrum-half O'Leary quick ball to launch his support down the blind side.
Nigel Davies' side rose to that in the opening period, matching the Tigers' renowned scrum power despite having a rookie at tight-head prop in Simon Gardiner.
Sheffield coach Mark Aston, his side's star player winning the Lance Todd Trophy when he played at scrum-half in that shock Wembley victory 12 years ago, was only briefly in dreamland.
"That's the mark of a very good side and Wales are capable of doing that at the moment, " Guscott told Scrum V.
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