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Hungarian-born scientist Leo Szilard, Fermi and other scientists knew they needed to leapfrog the bureaucracy.
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In the 1950s, Russian and American scientists knew there was no limit to the power of thermonuclear hydrogen bombs.
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By observing the cloud of dust and gas kicked up by each impact, scientists knew they could obtain valuable data about the Moon's composition.
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Even if the planet had life, scientists now knew, finding it would be extremely hard.
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The programme spoke to scientists who said they knew of no evidence of any nutritional benefit from eating organic food.
BBC: Organic food 'proven' healthier
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The U. S. Geological Service issued a report in April 2008 that only scientists and oil men knew was coming, but man was it big.
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The government presented internal industry documents that its lawyers hoped would indicate beyond doubt that scientists within the companies knew exactly what the true nature of tobacco was, even though the view presented to the public was much more benign.
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The British scientists of the 18th Century knew all about longitude.
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The scientists, for their part, knew little of art and literature -- or much cared.
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According to Dr. Steve Gardell, who led the teams, these scientists created a chemical to which they knew gamma secretase would bind.
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