Not all doctors are confident in its safety at its top dose.

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Vitamin manufacturers are to invited to submit evidence of the efficacy and safety of their high-dose products.

BBC: Clampdown on 'high-dose' vitamins

After studying the safety and efficacy of the low-dose pill, the ministry's Central Pharmaceutical Affairs Council agreed in February to approve oral contraceptives.

ECONOMIST: Japan

The drug has suffered because of concerns about safety and also the perception that the 40-mg top dose of Crestor is no better than Lipitor's 80-mg top dose.

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Dr. JOSHUA OFMAN (Vice President, Amgen): The FDA label acknowledges that a certain risks cannot be excluded, but they have clearly stated that the lowest dose should be use to avoid transfusion with an upper safety limit of 12, leaving some discretion for physicians to make those determinations based on their individual patient needs.

NPR: Doctors in Medicare Fight Over Right to Prescribe

Dr. Mann was looking mainly at the drug's safety, but he was surprised when patients started feeling less fatigued and more energetic after a single dose.

FORBES: Chemical Chameleon

Tularik was so concerned about safety that in phase-II trials for liver cancer, it tried the drug at a lower dose than it otherwise might have.

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