Other selection issues for manager Fabio Capello include whether to keep faith with striker Emile Heskey or bring in Tottenham's Peter Crouch.
The Dutchman stole in behind the home side's defence after Peter Crouch rose above Phil Neville to steer Alan Hutton's cross back into the six-yard area.
On Saturday, Aaron Lennon's injury-time goal won the match for Spurs after Birmingham's Lee Bowyer had cancelled out Peter Crouch's opener for the home side.
Portsmouth's England internationals Peter Crouch and Defoe showed some neat link-up play on 20 minutes with the former setting up the latter to shoot just over the bar from long range.
Rafa Benitez's decision to partner Peter Crouch with Torres had looked like a tactical blunder in the early stages, but it was a pairing that was to combine for their second goal.
Fulham's Bobby Zamora and West Ham's Carlton Cole both missed out on a striking berth, with Sunderland's 25-goal frontman Bent, Peter Crouch and Jermain Defoe of Spurs joining Villa's Emile Heskey and prolific Manchester United forward Wayne Rooney.
Beyond first-choice strike-duo of Rooney and Aston Villa's Emile Heskey, Capello has called-up Tottenham pair Jermain Defoe and Peter Crouch, Sunderland's Darren Bent, Heskey's Villa team-mate Gabriel Agbonlahor and West Ham's Carlton Cole ahead of Owen for England's successful World Cup qualifying campaign.
Niko Kranjcar put Spurs ahead, tapping in after Stephen Ireland had blocked Peter Crouch's initial header.
But Peter Crouch's simple finish gave Liverpool a second-half lead under the gaze of England manager Fabio Capello.
Peter Crouch's imminent move to Portsmouth means Liverpool are in the market for a new striker and on Tuesday Benitez admitted Villa was an option.
There was one more moment for Keane as he latched on to Peter Crouch's flick and shot through the legs of Jensen, the ball squirming over the line off the woodwork, and rather summing up Burnley's misery.
Tottenham's best chance came when Peter Crouch poked the ball just wide in the first half while Rafael van der Vaart went close with a header just before the break before shooting narrowly over following a late corner.
The Italians forced Spurs into a dogged rearguard action for long spells to protect the slender lead Peter Crouch's goal gave them from the first leg in the San Siro and ensure they succeeded where arch-rivals Arsenal failed in European combat.
It was Van der Vaart's final contribution as he was replaced by Peter Crouch, with Villa replacing the tiring Fabian Delph with veteran Robert Pires.
Prospective new owner Sulaiman Al Fahim's takeover of the club has still not been completed and two of last season's stand-out players - top scorer Peter Crouch and defender Glen Johnson - have both been sold - to Tottenham and Liverpool respectively.
In his absence, Tottenham will rely on fellow strikers Peter Crouch, Roman Pavlyuchenko and Robbie Keane while England could turn to Crouch, Fulham's Bobby Zamora or Sunderland striker Darren Bent who scored the third goal in Tuesday's 3-1 qualifying victory in Switzerland.
BBC: Tottenham star Jermain Defoe out for up to three months
Scholes picked up his first yellow card six minutes after the break, then Spurs striker Peter Crouch hit the crossbar before United's veteran midfielder received his marching orders for a second booking less than 10 minutes later.
Cudos as well to Peter Crouch, who bounced back from Tuesday's sending off with two well-taken headed goals.
Peter Crouch nodded Spurs ahead from Gareth Bale's cross and the striker and Tom Huddlestone then hit the woodwork.
Anton Ferdinand had an effort ruled out, substitute Peter Crouch headed Spurs back in contention but Boudewijn Zenden's stunning volley sealed it.
Keane had become Benitez's number one summer target over recent weeks, with the need to replace Peter Crouch, who joined Portsmouth earlier this month, seemingly more important than pursuing the protracted move for Aston Villa's 27-year-old midfielder Gareth Barry.
Tottenham's desperation was evident, with high balls going into the box aimed at substitute Peter Crouch but nothing came from them.
Redknapp also dismissed speculation linking England striker Peter Crouch with a move away from White Hart Lane and denied Sevilla's Brazil forward Luis Fabiano would be joining the club.
Due to the financial problems affecting the club during Alexandre Gaydamak's time as owner and the six-week reign of 10% stake-holder Sulaiman Al Fahim's, Hart was forced to sell a number of star players including Jermain Defoe, Peter Crouch and Glen Johnston.
He kept them up last season but lost several high-profile players such as Peter Crouch and Glen Johnson over the summer, and this season the club's ownership has been in doubt.
Tottenham, with former Pompey boss Harry Redknapp in charge and with one-time Fratton Park stars Jermain Defoe and Peter Crouch in their starting line-up, edged a colourless first 90 minutes before Grant's underdogs struck in the extra period.
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