Natalie Jones (SM6 200m IM) and Heather Frederiksen (S8 100m freestyle) were also in record-breaking form.
Giles Long missed out on his chance to complete a hat-trick of S8 100m butterfly crown.
BBC: SPORT | Other Sport | Paralympics | Kindred leads medal haul
Vehicles that offer this technology include the Audi S8 and Honda Odyssey minivan.
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Scotland's Sean Fraser won Para S8 100m freestyle silver behind Australia's Ben Austin, while England's Kate Haywood earned 100m breaststroke bronze.
Based on the A7, the four-door coupe pairs a 560-horsepower V8 engine from the S8 sedan with an AWD eight-speed automatic transmission.
Both Simmonds and Frederiksen broke world records in the S6 and S8 400m freestyle respectively at last month's British Swimming Championships in Sheffield.
There were also British records for Dave Ellis (S13 100m butterfly), Claire Cashmore (S8 50m and 100m breaststroke) and Anthony Stephens (S5 100m freestyle).
Even the Audi S8, which looks relatively conservative despite that grinning front grill and LED beams, comes off more elegantly aggressive than the CTS-V.
The action-based numbers get more dizzying on the S8 that ups the horsepower by 100 and speed from 0 to 60 in less than 4 seconds.
She will lose the gold she won in the S8 100m freestyle as well as silver from the SM8 200m individual medley and bronze from the S9 100m backstroke.
And the S8 comes from a brand that skews younger and cooler than Cadillac when it comes to its image and messaging in pop culture, which matters very much to young people with money.
In the men's Para S8 100m freestyle , Fraser edged between gold medallist Austin and fellow Australian Blake Cochrane to earn silver for Scotland in a British record 1:00.77, with David Roberts - 11 times a Paralympic champion - fourth for Wales, swimming against less-disabled athletes.
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