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Scharner pounced on the hour mark to turn the ball in at the far post after Emile Heskey's close range effort was parried by Derby keeper Roy Carroll.
BBC: Wigan 2-0 Derby
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Wigan's highly-rated goalkeeper Roy Carroll has also graduated to the full squad from the Under-21s, while McIlroy has also selected Carroll's clubmate Pat McGibbon and the uncapped Colin Murdock of Preston.
BBC: McIlroy rings the changes
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Roy Carroll is another man who left the English Premier League with a less than flawless reputation, but he was voted goalkeeper of the year in Denmark last season as he helped his new club to challenge Copenhagen.
BBC: Steelmen out to defy Danes
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On 16 minutes, Nani was allowed to pick up the ball on the half-way line and advance unchallenged towards the penalty area before letting fly with a ferocious shot that Roy Carroll got a hand to but could not keep out of his net.
BBC: Man Utd 4-2 Derby (4-3 agg)
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Maik Taylor (Fulham), Roy Carroll (Wigan), Aaron Hughes (Newcastle), Mark Williams (Watford), Danny Griffin (St Johnstone), Ian Nolan (Sheffield Wednesday), Colin Murdock (Preston), Pat McGibbon (Wigan), Kevin Horlock (Manchester City), Keith Gillespie (Blackburn), Damien Johnson (Blackburn), Michael Hughes (Wimbledon), Jim Magilton (Ipswich), Jeff Whitley (Manchester City), Danny Sonner (Sheffield Wednesday), Steve Lomas (West Ham), James Quinn (West Brom), Adrian Coote (Norwich), David Healy (Manchester United), Stephen Robinson (Bournemouth).
BBC: McIlroy rings the changes
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In a game it had to win if it harbored serious hopes of advancing from Group D, England coach Roy Hodgson named Andy Carroll, the 6-foot-3 center forward, to a lineup designed to unsettle Sweden and exploit a supposed weakness at crosses.
WSJ: Euro 2012: England Beats Sweden 3-2