Spurs were given enough evidence that they will have to up their game to overcome a Young Boys side who won 1-0 away at Fenerbahce in the last round to triumph 3-2 on aggregate and secure their progress to the play-off.
United, Liverpool, Chelsea and Rangers all reached the first round automatically, while Arsenal eased to a 5-1 aggregate victory over Celtic in qualifying to clinch their place in the lucrative stages of Europe's premier competition.
On that occasion, it was the first leg of a Champions League third-round qualifier and Chelsea beat the Slovakian side 2-0 before going on to win 5-0 on aggregate.