"It's not as if it's treading into a market where there are no other therapies, " says Robert Harrington, of Duke University.

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Orexigen says that it has already convened advisers for the trial including Robert Harrington and Robert Califf, both of Duke, and Steven Nissen, of the Cleveland Clinic.

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But Robert Harrington, a well-known Duke University Medical Center cardiologist, thought that the good and bad results from the drug made the study neutral, meaning there was no clear benefit from the medicine.

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That was part of the testimony of the first witness, Robert Grabowski, in the trial of Ross Mandell and Adam Harrington, all from Sky Capital.

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Irish Ryder Cup star Padraig Harrington made 67, with the British quartet of Malcolm Mackenzie, Robert Coles, Raymond Russell and Mark Pilkington still in touch with the leaders.

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