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But the home side hit back after the break through two tries each from Scott Donald, Rob Burrow and Gareth Ellis.
BBC: Leeds 38-22 Hull
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Leeds scored first through Chris Clarkson, but Quins ran riot with tries from Tony Clubb, Andy Ellis (2), Rob Purdham and Chris Bailey.
BBC: Leeds 26-36 Harlequins
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Ellis' solo homer in the fifth made it 2-all and finished reliever Rob Carson.
WSJ: Niese nicked, limps off as Mets lose to Dodgers
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The quartet of Leinster players - O'Driscoll, Rob Kearney, Luke Fitzgerald and Jamie Heaslip - plus Leicester's Tom Croft and Harry Ellis and Northampton prop Euan Murray were rested for the opening match after their exertions last weekend.
BBC: Earls given nod for Lions opener