In this week's issue of the "Proceedings of the National Academy of Sciences, " FitzGerald has published experiments showing that knocking out a gene in mice might decrease the risk of heart attacks while inhibiting pain.

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Global managers "might buy and sell the wrong stocks, but they might also get the allocations wrong among the various global equity sectors, and they might also allocate their portfolios in ways that significantly increase or decrease my risk level, " Mr. Curtis says.

WSJ: Are Global Funds a Better Way to Get World-wide Stock Exposure?