According to the box set's compiler, Ribas, business manager Ewart Abner in particular had some unusual practices.

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UCLA's Ribas calls the response rates "very low" and cautions that the anti-CTLA-4 drugs are just a first step.

FORBES: Targeting Melanoma

He continued flying back quarterly to see UCLA oncologist Antoni Ribas for infusions.

FORBES: Targeting Melanoma

"It's the hallmark of immune therapy--it doesn't happen often, but once it happens, those patients live years, " says UCLA oncologist Antoni Ribas.

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Middleton's well-taken second-half goal was little more than consolation for Britain and Ribas' late goal set the seal on a dominant Spanish performance.

BBC: Spain thrash Great Britain

Britain spent the next 15 minutes defending and the predictable outcome was another penalty-corner goal, with Ribas' low drag flick going through Mason's legs.

BBC: GB could not hold their lead

"It is what we have been waiting for to see in melanoma for years, " says University of California, Los Angeles, melanoma expert Antoni Ribas, who is involved in the trial.

FORBES: American Society of Clinical Oncology

But Spain were level within three minutes when Ribas' drag flick from the hosts' seventh penalty corner was only half-stopped by Mason's left hand and the ball trickled over the line.

BBC: GB could not hold their lead