Isaiah Morton's 3-pointer with 43 seconds remaining in the second overtime put the RedFoxes (6-18, 3-10 Metro Atlantic Athletic Conference) ahead, 101-100.
After Pickrel's surge gave Michigan State a 25-16 halftime lead, the Spartans allowed the RedFoxes to get back in front with a flurry of 3-pointers, prompting coach Suzy Merchant to call timeout and deliver a very simple message.
Casey Dulin scored 13 points to lead the RedFoxes (26-7), who have made a name for themselves by winning first-round games as double-digit seeds, advancing to the second round as a No. 13 a year ago and as a No. 10 in 2011.