It blocks stimulation of a specific receptor in the brain, an NMDA receptor.
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His lab showed this protein to be the receptor for VEGF, and that blocking the receptor stunted the growth of tumors in lab animals.
In 1999 Buck deciphered a sort of alphabet, or code, in which each receptor detects more than one odorant, and each odorant can be detected by more than one receptor.
When researchers engineered mice to lack the "alternative receptor" which binds to dioxins, the mice, evidence emerged which suggested that this receptor played a role in the immune system, the liver, ovaries and other organs.
First, by using radioactive tracers to track the behavior of hormones, Lekfowitz was able to identify and extract unique receptor molecules protein assemblies on the surface of cells including the receptor for the well-known fight-or-flight hormone, adrenaline.
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To make their mice hypersensitive to explosives, the researchers altered the gene responsible for the DNT receptor so that the transgenic mice have as many as one million neurons in which the odor receptor is tuned to the fragrance of a land mine.
Recently there has been a resurgence of interest in ketamine because of studies showing that at much lower doses than required for anesthesia, it appears to be a rapid and powerful antidepressant agent, presumably because it blocks an important type of receptor in the brain, known as the NMDA receptor.
Instead of targeting thrombin directly, SCH 530348 blocks the receptor that thrombin triggers on platelets.
DeCode is now screening for compounds to target the gene and a key receptor.
Stimulating the 5-HT2C receptor alone does not appear to cause hallucinations or heart valvular problems.
It was even better when compared to the 2B (heart valve) receptor, 11.6 times more selective.
Classic drugs that cause hallucinations LSD and mescaline act by stimulating the 5-HT2A receptor.
ImClone's Erbitux blocked the EGF receptor in a slightly different way, using an injectable monoclonal antibody.
That was a dead end, but Schering was desperately seeking a thrombin receptor drug.
Veltri also had been running the development of another Schering-invented drug, the thrombin receptor antagonist vorapaxar.
Moreover, weak drugs targeting a PPAR receptor associated with heart disease have been around for decades.
DeVico's idea was to build a vaccine consisting of gp120 permanently fused to its CD4 receptor.
According to Sanofi's Ellison, the medicine blocks a receptor in the brain involved in stimulating appetite.
Dr. Brentjens and a fellow co-author hold a patent on the engineered T-cell receptor.
Instead of turning the patient's overactive dopamine receptor off, it dims it a bit.
While Sugen targeted the receptor for VEGF, Genentech was focusing on the protein itself.
Avandia works by hitting a drug target called the peroxisome proliferator-activated receptor (PPAR) gamma.
The mutation freezes a crucial protein called epidermal growth factor receptor in the "on" position.
The team also did some laboratory experiments, which showed that HIV binds to the receptor.
They blocked the D2 receptor just enough to alleviate psychoses without obliterating the patient.
Later, Kobilka isolated the specific gene that serves as a DNA blueprint for that adrenaline receptor.
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Drugs included angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs) and diuretics, with NSAIDs.
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It is associated with particular variants of receptor molecules for neurotransmitters in the brain.
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The issues relate to an oestrogen receptor test, which detects whether patients would benefit from hormone treatment.
Second-generation drugs introduced in the 1990s stick to the receptor some of the time, but not always.
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