Asthma inhalers like albuterol, which work by stimulating beta-receptor cells in the lungs, were first used to treat high-altitude climbers.
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In theory, the medicines could affect the immune system, because a receptor on immune cells is very similar to DPP-4.
Anadys Pharmaceuticals is in early-stage human tests with drugs that stimulate the so-called TLR-7 receptor on immune cells to produce interferon just where it is needed.
In one experiment 60% of mice missing something called the gamma interferon receptor on their cells got tumors after being exposed to a carcinogen, versus only 15% of normal mice.
We will routinely turn off genes that promote disease and aging such as the fat insulin receptor gene that tells the fat cells to hold onto excess fat.
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Dopamine-producing nerve cells have acetylcholine-receptor molecules on their surfaces.
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Dr He and his colleagues looked at the genes of airmen who classified themselves as black and found that the ones infected with HIV were more likely to lack red cells bearing the Duffy receptor than chance would suggest.
But instead of targeting the growth factor, it blocks the receptor by which it VEGF attaches to cells.
The mutation means that Duffy receptor proteins are not made in red cells.
Ideally, when finding a drug, scientists start with a crystal structure of receptor proteins found on the surfaces of cells.
Lorcaserin was more selective in receptor-stimulated inositol phosphate accumulation in the same cells.
The molecule - epidermal growth factor receptor (EGFR) - relays instructions to cells to grow and divide, and to ignore signals telling them to die.
For example, a genetic database created by Spectra Biomedical, a division of Glaxo Wellcome, found an unexpected correlation between migraine attacks, serious depression and variations in the dopamine D2 receptor (a molecule that sticks out of certain nerve cells).
In 1987 Biogen and Harvard University scientists were experimenting with a receptor called CD-2, situated on the surface of T cells.
In the early 1990s a scientist at the National Cancer Institute had discovered that an already-existing molecule clings to a receptor on heat-shock proteins, preventing the survival of cancer cells.
All three drugs target the epidermal growth factor receptor (EGFR), a protein that is over-expressed in cancer cells.
The public has mostly focused on Erbitux's ability to slow tumor growth by blocking epidermal growth factor receptor, a key growth-promoting protein that is overabundant in many cancer cells.
HINT, crops up in 11 different genes for receptor proteins that sit on a cell's surface waiting for messenger molecules from other cells.
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