And the unseeded outsider took it 7-4 to reach round four for the first time.
But Serena Williams beat Vera Dushevina 6-7 7-6 7-6 to reach round three.
By the end of play on day two, six of the nation's seven representatives had fallen by the wayside, leaving Andy Murray as the only home player - male or female - to reach round two.
Blue scored 19 second-half points to rally third-seeded Marquette out of another hole, and the Golden Eagles survived 74-72 on Saturday to reach the round of 16 in the NCAA tournament.
The Admissions Committee then starts to offer admission to the best candidates, and by the time you reach the round two deadline in January (my dates and figures are purely illustrative), there may be 250 or so places left.
Del Potro beat compatriot Leonardo Mayer in straight sets to reach the fourth round.
Federer will next meet Gustavo Kuerten, who beat Goran Ivanisevic 6-2 6-4 to reach the second round.
Takao Suzuki beat 10th seed American Jan-Michael Gambill to reach the second round of the Japan Open.
In all, Williams hit six aces and won 32 of 39 service points to reach the third round.
The Argentine won 6-0 6-4 to reach the second round, with Briton Andy Murray a potential quarter-final opponent.
Italy's Silvia Farina Elia edged South Arican Amanda Coetzer 7-6 7-6 to reach the second round in Filderstadt.
Crawley are the first non-league team for 17 years to reach the fifth round of the FA Cup.
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Sixth seed Nikolay Davydenko was the first man to reach the third round, seeing off Igor Kunitsyn 6-4 6-2.
And he said he would love to help the Bulls reach the third round and then draw his parent club.
Elsewhere, fifth seed Robin Soderling of Sweden beat Italian wild card Paolo Lorenzi 6-1 7-5 to reach the third round.
And this year, he upset 22nd seeded Florian Mayer and top 100 player Flavio Cipolla to reach the third round.
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The 6ft 6in 31-year-old Czech keeper replaced regular choice Casper Ankergren as a reward for helping Brighton reach the fifth round.
If they win they will become the first Kent League side to reach the first round since Ramsgate Athletic in 1956.
Reigning Wimbledon champion Maria Sharapova hit two aces and 15 winners to beat Angela Haynes 6-1 6-2 and reach the third round.
Andy Murray continued his quest for an Olympic singles medal by beating Finland's Jarkko Nieminen to reach the third round at Wimbledon.
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Tsonga was swept aside in the first set but quickly regained control to win 1-6 6-3 6-2 6-4 to reach the second round.
Russian second seed Mikhail Youzhny defeated German Andreas Beck 6-3 6-3 to reach the third round, where he faces Jan Hajek of the Czech Republic.
Jo-Wilfried Tsonga won in straight sets to reach the third round.
They overcame one to reach the second round of the playoffs.
The 26-year-old had been tipped to reach the second round with Martic ranked 15 places below her and having only been at Wimbledon once before.
Holder Svetlana Kuznetsova overcame a shaky start to reach the second round of the French Open with a straight sets victory over Romania's Sorana Cirstea on Sunday.
Baltacha got some valuable grass-court practice at Eastbourne, going through qualifying to reach the second round of the main draw where she was beaten by fifth seed Nicole Vaidisova.
Last year she became the first Indian woman to reach the fourth round of the US Open, although she went out in the second round of the recent Australian Open.
He next plays No. 13-seeded Kei Nishikori, who became the first Japanese man in 75 years to reach the fourth round at Roland Garros, beating Benoit Paire 6-3, 6-7 (3), 6-4, 6-1.
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