Some researchers worried an mTOR drug would suppress patients' immune systems, as Rapamune does by design.

FORBES: Magazine Article

Mice who were fed the transplant drug Rapamune late in their lives lived longer than mice in a control group.

FORBES: Magazine Article

The mice in Harrison's study lived longer after getting Rapamune when they were a year-and-a-half old, which is old age for a mouse.

FORBES: Magazine Article

Rapamune, sold by Wyeth, suppresses the immune system and raises the risk of infection, so this study isn't a reason to start taking it.

FORBES: Magazine Article

They already have contributed to the development of the antibiotics erythromycin and tetracycline, the cancer chemotherapy drug doxorubicin, Wyeth's transplant drug Rapamune, and Merck's cholesterol-lowering medicine, Mevacor.

FORBES: A Dirty Business

The drug works by tripping a cellular switch that was discovered serendipitously by scientists studying an unrelated drug--Rapamune, a Wyeth chemical used to suppress the immune systems of organ transplant patients.

FORBES: Magazine Article

The active ingredient in Rapamune, rapamycin, was discovered decades ago but scientists didn't understand how the drug worked until a graduate student named David Sabatini discovered the mammalian target of rapamycin (mTOR), a protein that acts as part of a complicated set of chemical signals that causes cells to divide.

FORBES: Magazine Article