"The biggest mistake of ablation was that there wasn't a big randomized study when the technology came out, " he says.
In this large, randomized study, Erbitux shrank colon cancer tumors by at least half in 23% of patients when used with chemotherapy, and 11% when used alone.
Previous observational studies have also suggested that aspirin could be an effective tool against cancer, but this is the first randomized study to test the hypothesis directly.
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It is a randomized controlled study, meaning that similar patients were assigned at random to either get either Centrum or placebo.
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The Symplicity HTN-2 trial is an international, multi-center, prospective, randomized, controlled study of renal denervation in patients with treatment-resistant hypertension.
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The results were shown in the first randomized phase II study comparing trastuzumab-DM1 (T-DM1) to Herceptin (trastuzumab) plus chemotherapy (docetaxel), the current standard of care for first line HER2-positive metastatic breast cancer.
This randomized, controlled study showed that Medicaid coverage generated no significant improvements in measured physical health outcomes in the first 2 years, but it did increase use of health care services, raise rates of diabetes detection and management, lower rates of depression, and reduce financial strain.
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The latest study, a randomized trial of 80 women and men published in Plos One by Harvard researchers, shows that even when clinicians told women with irritable bowel syndrome they are getting fake pills, the fake pills still worked.
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In addition to his many papers exploring the basic science of the renin-angiotensin system, Matsubara was the chief investigator of the KYOTO HEART Study, a randomized, open-labeled trial studying the add-on effect of valsartan to conventional therapy in high-risk hypertension.
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There has been only one study using a large randomized sample, objective measures of well-being, and reports of grown children rather than their parents.
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Among other limitations of the studies: Patients whose claims were analyzed in the MD Anderson study weren't randomized to either treatment, nor did researchers know why patients had mastectomies.
Because the Framingham Heart Study is not a randomized controlled trial, it's still not clear if vitamin D is the real reason for the link (the vitamin's levels could drop in unhealthy people for other reasons), or if taking a supplement would lower the risk.
Medical research commonly employs three kinds of study designs: observational studies, randomized controlled trials (RCTs), and metaanalyses.
Despite some limitations of trial design, including the open label nature of the study, RECORD remains the only randomized trial of cardiovascular outcomes for Avandia at this time.
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For one, the groups noted the analysis is a retrospective study, not a prospective, randomized controlled clinical trial, which many regard as a gold standard for ferreting out safety concerns.
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All of the studies ran for at least a year, and all were randomized controlled trials, the most rigorous type of study.
In one study, researchers analyzed patient data from 51 randomized trials that were designed to observe aspirin's ability to prevent vascular events such as heart attacks.
To really know whether antidepressants have long-term health risks, one would have to do a very, very large study in which 50 percent of the subjects were randomized to receive an antidepressant and the other 50 percent were randomized to take a placebo pill.
The RAND study, which followed 2, 750 families who were randomized into different kinds of insurance where out of pocket costs varied, did not specifically pose the question of whether having health insurance makes you healthy.
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In a 28-week study of Alzheimer's patients, 250 were in a randomized trial to memantine or placebo.
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The Cambridge group will begin a randomized controlled trial next month with 104 children involved, similar to the peanut study done already, but with controls, said researcher Dr. Andrew Clark of Cambridge University Hospitals.
Dr. Hartwell, who wasn't involved in the study, said social-network trials aren't likely to replace conventional randomized, double-blinded, placebo-controlled trials, the gold-standard for generating medical evidence.
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But there has been only one randomized controlled trial studying the effectiveness of taking foods out of so-called elimination diets, Chafen's study said.
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