Medical research commonly employs three kinds of study designs: observational studies, randomized controlled trials (RCTs), and metaanalyses.
Twenty-one of the studies included in the review were randomized controlled trials, which are considered the gold standard for scientific research.
All of the studies ran for at least a year, and all were randomized controlled trials, the most rigorous type of study.
The Komen Web site cites a meta-analysis of the the two largest randomized controlled trials, one from China and one from Russia.
Two randomized controlled trials in England and the Netherlands have shown that supplementing the diets of young prisoners with omega-3 reduced serious offending by 35%.
Proponents and skeptics alike agree on the need for data from randomized controlled trials to provide better information to guide use of the new procedure.
There have not been any large randomized controlled trials regarding coffee's health benefits, or even to see whether caffeinated or decaf is better for you.
We know from dozens of randomized controlled trials that medications ranging from stimulants to antipsychotics to mood stabilizers are surprisingly effective in reducing aggression in children and adolescents.
We have a set of plausible and interesting hypotheses to work with, and now we need some randomized controlled trials to give us data we can really use.
Several studies that followed large groups of people as they aged have suggested that a diet rich in fish is linked to a reduced risk of dementia and mental decline, but most randomized controlled trials comparing DHA supplements with placebo have found no benefit.
But randomized controlled clinical trials also are used to prove benefit in big drug studies.
Moreover, he says, based on data from other randomized, controlled trials, he doesn't see big differences between any of the COX-2 drugs.
Controlled, randomized trials will help validate these promising starts.
The safety and efficacy of Belviq were evaluated in three randomized, placebo-controlled trials that included nearly 8, 000 obese and overweight patients, with and without type 2 diabetes, treated for 52 to 104 weeks.
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Dr. Hartwell, who wasn't involved in the study, said social-network trials aren't likely to replace conventional randomized, double-blinded, placebo-controlled trials, the gold-standard for generating medical evidence.
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Safety data for KYNAMRO are based on pooled results from four Phase 3, randomized, double-blind, placebo-controlled trials with a total of 390 patients of which 261 patients received weekly subcutaneous injections of 200 mg of KYNAMRO and 129 patients received placebo for a median treatment duration of 25 weeks.
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