But randomized controlled clinical trials also are used to prove benefit in big drug studies.
The treatment was common until a randomized controlled trial proved it was actually harming women.
Medical research commonly employs three kinds of study designs: observational studies, randomized controlled trials (RCTs), and metaanalyses.
It is because the government-funded trial was a placebo-controlled, double-blind, randomized controlled trial.
But a related Abbott drug, TriCor, failed to prove its benefits in a large randomized controlled clinical trial.
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Twenty-one of the studies included in the review were randomized controlled trials, which are considered the gold standard for scientific research.
It is a randomized controlled study, meaning that similar patients were assigned at random to either get either Centrum or placebo.
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All of the studies ran for at least a year, and all were randomized controlled trials, the most rigorous type of study.
The Komen Web site cites a meta-analysis of the the two largest randomized controlled trials, one from China and one from Russia.
But there has been only one randomized controlled trial studying the effectiveness of taking foods out of so-called elimination diets, Chafen's study said.
Two randomized controlled trials in England and the Netherlands have shown that supplementing the diets of young prisoners with omega-3 reduced serious offending by 35%.
But I think that before embarking on a large randomized controlled trial he first needs to demonstrate that such a trial would even be feasible.
Proponents and skeptics alike agree on the need for data from randomized controlled trials to provide better information to guide use of the new procedure.
There have not been any large randomized controlled trials regarding coffee's health benefits, or even to see whether caffeinated or decaf is better for you.
We know from dozens of randomized controlled trials that medications ranging from stimulants to antipsychotics to mood stabilizers are surprisingly effective in reducing aggression in children and adolescents.
We have a set of plausible and interesting hypotheses to work with, and now we need some randomized controlled trials to give us data we can really use.
More substantial and convincing support for such a recommendation to eat cherries as a way to reduce gout flares would ideally emerge from a randomized controlled clinical trial.
In healthcare, our gold standard for good evidence is the randomized controlled trial, in which, for example, half the patients receive a new drug and half receive a placebo.
For one, the groups noted the analysis is a retrospective study, not a prospective, randomized controlled clinical trial, which many regard as a gold standard for ferreting out safety concerns.
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Many people enthusiastically tried the so-called Feingold Diet, but the enthusiasm waned as the years went on and "some very well-done randomized controlled studies" questioned Feingold's theory, says Deborah Pearson, Ph.
The Cambridge group will begin a randomized controlled trial next month with 104 children involved, similar to the peanut study done already, but with controls, said researcher Dr. Andrew Clark of Cambridge University Hospitals.
Several studies that followed large groups of people as they aged have suggested that a diet rich in fish is linked to a reduced risk of dementia and mental decline, but most randomized controlled trials comparing DHA supplements with placebo have found no benefit.
Because the Framingham Heart Study is not a randomized controlled trial, it's still not clear if vitamin D is the real reason for the link (the vitamin's levels could drop in unhealthy people for other reasons), or if taking a supplement would lower the risk.
But surgery sometimes goes mainstream without ever being evaluated in a randomized, controlled trial.
He currently is recruiting post-stroke patients for a randomized, controlled trial comparing error-type treatment to intensive treadmill training.
The Symplicity HTN-2 trial is an international, multi-center, prospective, randomized, controlled study of renal denervation in patients with treatment-resistant hypertension.
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Moreover, he says, based on data from other randomized, controlled trials, he doesn't see big differences between any of the COX-2 drugs.
These are the kinds of big, randomized, controlled studies that the U.S. Food and Drug Administration requires before a new drug is approved.
The investigators are now conducting a randomized, controlled clinical trial of RAGE Control in the outpatient clinic at Boston Children's that adds a cooperative component.
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In the accepted hierarchy of evidence generation, the results of a randomized, controlled clinical trial usually take precedence over other forms of evidence such as meta-analysis and observational studies.
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