It is because the government-funded trial was a placebo-controlled, double-blind, randomized controlled trial.
The safety and efficacy of Belviq were evaluated in three randomized, placebo-controlled trials that included nearly 8, 000 obese and overweight patients, with and without type 2 diabetes, treated for 52 to 104 weeks.
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He currently is recruiting post-stroke patients for a randomized, controlled trial comparing error-type treatment to intensive treadmill training.
Many people enthusiastically tried the so-called Feingold Diet, but the enthusiasm waned as the years went on and "some very well-done randomized controlled studies" questioned Feingold's theory, says Deborah Pearson, Ph.
The Symplicity HTN-2 trial is an international, multi-center, prospective, randomized, controlled study of renal denervation in patients with treatment-resistant hypertension.
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Dr. Hartwell, who wasn't involved in the study, said social-network trials aren't likely to replace conventional randomized, double-blinded, placebo-controlled trials, the gold-standard for generating medical evidence.
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The randomized, double-blind, placebo-controlled, multi-center trial enrolled 51 patients age 12 to 53 years, including 7 patients age 12 to 16 years, who were maintaining a regimen of maximally-tolerated lipid lowering medications.
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Safety data for KYNAMRO are based on pooled results from four Phase 3, randomized, double-blind, placebo-controlled trials with a total of 390 patients of which 261 patients received weekly subcutaneous injections of 200 mg of KYNAMRO and 129 patients received placebo for a median treatment duration of 25 weeks.
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It was not placebo-controlled, blinded, or randomized, which presents major methodological problems regardless of what happened.
The Komen Web site cites a meta-analysis of the the two largest randomized controlled trials, one from China and one from Russia.
Twenty-one of the studies included in the review were randomized controlled trials, which are considered the gold standard for scientific research.
But there has been only one randomized controlled trial studying the effectiveness of taking foods out of so-called elimination diets, Chafen's study said.
In the accepted hierarchy of evidence generation, the results of a randomized, controlled clinical trial usually take precedence over other forms of evidence such as meta-analysis and observational studies.
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Moreover, he says, based on data from other randomized, controlled trials, he doesn't see big differences between any of the COX-2 drugs.
Two randomized controlled trials in England and the Netherlands have shown that supplementing the diets of young prisoners with omega-3 reduced serious offending by 35%.
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