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Karachi politics has long been controlled by the Muttahida Quami Movement, the party representing migrants from what is now India.
WSJ: Karachi Beset by Political Strife
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This violence also makes itself felt politically and there is profound antagonism between the local chapters of three political parties: the Pakistan People's Party (PPP), the mostly Pashtun Awami National Party (ANP) and the Muttahida Quami Movement (MQM).
BBC: How the Taliban gripped Karachi
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Others have been casting doubts on the Muttahida Quami Movement (MQM) - the largest and most organised political party of the city which is a partner in power both at the provincial and central levels but whose relations with the ruling Pakistan People's Party (PPP) have soured over the past couple of months.
BBC: Karachi bomb was 'caused by IED'