The technology humbled some once promising outfits, like Danny Hillis' Thinking Machines and Larry Ellison's ncube.
When his once promising baseball career was derailed by an arm injury, he quickly channeled his competitive drive into entrepreneurship.
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Once promising partners are identified, they are often vetted by traditional marriage-brokers.
The low point in his once promising career occurred in 2010 when he was left off the postseason roster as the Giants won their first world championship in San Francisco.
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One of the few success stories in a market in which many have failed, the company in recent years has swallowed up the remnants of once promising photo sites owned by Sony, Yahoo, American Greetings and, more recently, Kodak.
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Look at Mexico, once a promising country, starting to develop, developing a middle class.
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Meanwhile, the drug companies themselves have been dropping or reducing research into fields that once looked promising.
At Pfizer, sales of top seller Lipitor actually dipped slightly, while Chantix, a once-promising anti-smoking drug, saw sales plummet.
Doubts grew that Avastin wouldn't work, or that some serious side effect such as gastrointestinal bleeding would ground the once-promising drug.
Digital ownership and distribution of goods has profound implications for consumers that are at once extremely promising and absolutely frightening at the same time.
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Connecticut was written by Justice Ruth Bader Ginsburg and shuts down a once-promising avenue for lawyers to try and control CO2 through the courts.
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There are plenty more months and years of prison to be tagged on to some people who once had promising careers on and off Wall Street.
Pfizer, for instance, has had its share of problems, including the recent announcement that it is suspending work on a once-promising drug to boost levels of good cholesterol.
The former Disney star has been under some form of probation since she was arrested twice in 2007 for driving under the influence, and her court troubles have stifled a once-promising career.
Republicans lost seats in the GOP-controlled House, failed to capitalize on a once-promising shot at winning the Senate majority and the party's presidential nominee, former Massachusetts Gov. Mitt Romney, failed to unseat Obama.
As for Colbert Busch, she has refused to exploit the latest image problem of the man who once was mentioned as a potential presidential contender before his affair with a woman in Argentina and ethics violations left a once-promising career in ruins.
Ministers are promising a draft Pensions Bill once a commission on the issue reports.
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Recognizing the severity of the crisis, the commission boldly met once a month promising a report in December 2010.
And with all due respect to Brendan and the other winners, the singularly most promising business idea has not once won, in my opinion.
High rates of foreclosure in bubble states have freed workers to leave for more promising markets, including the once too-expensive cities from which such migrants previously fled.
We can't really see Apple going it alone on this one for hardware's sake, and their partnership with Moto, which once seemed so promising, now appears rocky at best after the nano quasi-betrayal (his namely evidenced by Moto's wandering musicphone eye, lining up some seriosu musicphones without iTunes left and right post ROKR E1, like the ROKR E2).
But victories, he argues, will allow investors to once again focus on promising experimental medicines, like Gardasil, a vaccine to prevent cervical cancer, and a new diabetes pill.
Once, Casey met a promising inventor who had recently won a contract with the Army.
Rudd, who had once been considered a very promising leader, did not even get to contest another election.
American business schools were once popular places to send promising young sararimen, and hundreds enrolled from big Japanese firms every year.
The situation here reminds me a little bit of the biotech stocks: everyone is all excited about the unlimited prospects when a promising new drug is in trials, but once it hits the market, the company turns into a mundane pharmaceutical company that has to actually sell something.
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Genentech's Avastin was once seen as one of the most promising cancer fighters around.
Once one of Africa's most promising economies, Zimbabwe is reeling under its worst humanitarian and economic crisis.
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They also show once again that liberals are good at promising the blessings of government largesse but they leave its messes for others to clean up.
Elan and American Home Products have ended trials of their Alzheimer's vaccine--once seen as one of the most promising new approaches to treating the disease--after 15 patients suffered a potentially serious side effect: swelling of the central nervous system.
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