Arena Pharmaceuticals' experimental obesity drug passed a crucial safety test, but it may take at least six more months before worries about a potential side effect really start to abate.

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Although one character makes light of his heart failure, he is presented as a ridiculous and unbalanced individual whose conduct here and elsewhere is unlikely to encourage emulation or the belief that this is a harmless and temporary potential side-effect.

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Nor is there much worry about a potential nasty side-effect of a booming current-account surplus: rising inflation.

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In cases where the side-effect has a genetic root, failures could be averted by excluding potential victims from trials and, of course, from treatments after the drug is approved.

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Poor circulation has a number of potential causes, including blocked arteries, varicose veins, liver or kidney disease, extreme cold, or as a side effect of certain drugs or medications.

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