Cerys spoke openly of her depression, the physical strain of touring, and the mental anguish of pop stardom.

BBC: Catatonia: Equally cursed and blessed

Originally created for the U.S. Department of Defense at the University of Iowa as part of the Virtual Soldier Research (VSR) program to help reduce physical strain on soldiers, Santos has been heralded by ergonomists as a breakthrough in digital modeling.

ENGADGET: SantosHuman's Virtual Soldier recruited by Ford for assembly line detail

Jackie Sanders says the combination of physical and emotional strain, combined with the lack of sleep, can take its toll.

BBC: 'Always on edge' - a carer's life

Confirming this strain on physical silver supplies, just this morning the RCM went on allocation, limiting the quantity of sales of the popular Silver Maple Leaf coin.

FORBES: Royal Canadian Mint 'Managing' Silver Supply

Even for people in top physical condition, that can cause a lot of strain and fatigue.

FORBES: DARPA Robot Carries Heavy Loads So Soldiers Don't Have To