Second, Bristol-Myers Squibb stopped a Phase II study of its BMS-094 for hepatitis C because of a serious safety issue.
This is a horrific tale of six young males who, in 2006, volunteered for a phase 1 study for a novel drug, TGN1412.
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Today it is unveiling more data from that Phase III study, showing exactly how much Lucentis improved vision in AMD patients versus a placebo injection.
For its part, Merck notes that its BACE inhibitor recently demonstrated a reduction in cerebral spinal fluid, or CSF, a biomarker, in a Phase I study.
Recall that a few patients in the phase III study presented last fall at ACR also experienced heart failure, but that TNFs are also associated with heart failure.
The results were shown in the first randomized phase II study comparing trastuzumab-DM1 (T-DM1) to Herceptin (trastuzumab) plus chemotherapy (docetaxel), the current standard of care for first line HER2-positive metastatic breast cancer.
Naurex said the main side effects in a Phase IIa study of its GLYX-13 compound with 116 people with depression were headache and sleepiness, similar to the effects of a placebo saline injection.
The tough path to getting a drug to market was demonstrated Monday, as Pfizer Inc. said a highly anticipated potential treatment for Alzheimer's failed to reach its goals in a Phase 3 study.
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The treatment, CYT387, appears to demonstrate an ability to render and maintain myelofibrosis patients transfusion independent for clinically-relevant periods, while also improving other symptoms, according to a phase I and phase II study.
In contrast, the American Psychiatric Association highlights the fact that a phase 3 study of the vaccine reported in 2011 yielded disappointing clinical results, demonstrating that the vaccine was no more effective than placebo.
In the first stage of a phase III study called CLL11, the drug in combination with chemotherapy significantly reduced the risk of disease worsening or death compared to chemotherapy alone in previously untreated patients.
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The specific drug tested in the trial -- Idelalisib -- was shown in a first phase of study to be safe in high-risk populations, and to help reduce the size of affected lymph nodes for long periods of time.
Results of a Phase 1 study, rcently presented at the 2011 Annual Meeting of the American Society of Hematology, showed three of five patients in their second or third remissions had longer complete responses with CNDO-109 than with other therapies, says Dr. Markey.
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After Week 26, during the safety phase of the study, adjustments to concomitant lipid-lowering treatments were allowed.
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It will use off-the-shelf components. (8) The reactor is in the study phase.
The mortality benefit observed during the treatment phase of the study was maintained.
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So why does this tiny Phase I pilot study, successful for only four of six women, matter so much?
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Cartwright has described that system, now entering its second study phase, as a key component in transforming the aging Cold War nuclear weapons stockpile.
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These positive results help pave the way for the pivotal Phase III efficacy study that will recruit up to 16, 000 children and infants at 11 trial sites in seven countries.
The company recently completed enrollment in a Phase I clinical study of MultiStem in heart attack patients, and is midway through a clinical study of MultiStem in leukemia and other cancer patients.
In the first phase of the study, the researchers showed that their volunteers (Surrey university students) were slower to notice a target shade of blue when it flashed up against a blue background of a different hue than when it flashed up against a green background.
The field of study investigating the coming phase shift is known as Complex Adaptive Systems.
The report concludes only the first phase of the Institute of Medicine study.
"The most important trial we have is this phase-III single-agent study which compares daily Tarceva with best-supported care, " says Goddard.
In September 2010, First Solar finally received approval for a pre-feasibility study for the first phase of the Ordos project.
These are some of the conclusions of the second phase of an eight-month study on the evolving workforce commissioned by Dell and our partner Intel.
Ahead of last week's ICANN meeting in Yokohama, Japan, however, controversy erupted when the group's staff proposed amending ICANN's bylaws not just to conduct the study but also to phase out the existence of the nine at-large directors within two years.
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BioSante reported that with 2, 869 women enrolled and over 3, 000 women-years of exposure in it LibiGel Phase III cardiovascular and breast cancer safety study, there have been 17 adjudicated cardiovascular (CV) events, with a lower than anticipated event rate of approximately 0.57 percent.
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