In clinical trials, Cincinnati's Nasrallah notes, Vietnam veterans did not respond to Zoloft and Paxil.
Glaxo was defending its Paxil, an antidepressant, against a challenge from generic drug maker Apotex .
First, your doctor might add a second antidepressant or an atypical antipsychotic to your Paxil.
Now, it is losing market share rapidly to competitors such as Pfizer's Zoloft and SmithKline Beecham's Paxil.
More importantly, it is possible that Paxil is still protected by other patents.
New data have forced antidepressants, like Paxil and Zoloft, to carry warnings that they may cause suicidal thoughts in adolescents.
Even if Apotex does bring a version of Paxil to market, that may not spell doom for the Paxil franchise.
By contrast, Paxil ramped up activity in the cortex, while dampening activity in the limbic parts of the brain responsible for emotions.
Second, your doctor might switch you from the Paxil to another antidepressant.
New York Attorney General Eliot Spitzer sued Glaxo in 2004 for not disclosing negative data that linked Paxil to suicidal thoughts in children.
FORBES: With Transparency Pledge, Glaxo Makes Promises No Other Drug Company Has
GSK, maker of Paxil, the antidepressant, and Flonase, an antiallergy steroid, wants to appear open and accessible at a time when drug companies are on the defensive.
Your doctor may prescribe one of several selective serotonin reuptake inhibitors (SSRIs), such as sertraline (Zoloft), paroxetine (Paxil) or fluoxetine (Prozac), to help delay ejaculation.
" It added, "Since its approval by the FDA in 1992, Paxil has helped millions of people battling mental illness lead more productive, happier lives.
It is not clear how long you have been on the Paxil (generic: paroxetine), but let's assume you've been on it for at least six weeks.
The London-based giant announced that it had lost a Chicago court case that could expose antidepressant Paxil, one of Glaxo's best-selling drugs, to a generic competitor.
GlaxoSmithKline, also based in the United Kingdom, has a stable of well-known brands, including respiratory (Advair and Ventolin), antiviral (Combivir) and anxiety (Wellbutrin and Paxil) treatments.
Scientists believe glutamate is a much more direct target for depression than serotonin, a neurotransmitter affected by selective serotonin reuptake inhibitor (SSRI) drugs like Prozac and Paxil.
Last year, antidepressant medicines such as Prozac and Paxil came under scrutiny as to whether they actually might increase the chance of suicide in children and adolescents.
Arnold says Glaxo already has managed to switch 30% of Paxil patients to Paxil CR, a controlled-release version that lasts longer and may deliver a more sustained dose.
So-called selective serotonin reuptake inhibitors such as Paxil, Prozac and Zoloft, gained widespread use on the theory that depressed people suffer from a deficit of the brain chemical serotonin.
And last August GSK settled a suit filed by New York Attorney General Eliot Spitzer, who accused the company of failing to publish negative studies about unapproved use of its antidepressant Paxil.
As with other compulsive behaviors like gambling and drinking, Delmonico recommends therapy and 12-step programs, although antidepressants (drugs llike Paxil or Zoloft) and antipsychotics like (these include Abilify and Zyprexa) may help.
The strategy there is much like the one for Paxil: A newer formulation of Augmentin seems to have some advantages over the old standby but is much more expensive than the generic.
Paxil CR and Paxil have not been directly compared with one another, but in studies comparing each to placebo, patients were less likely to stop taking the controlled-release version because of side effects.
For proof, one need only ask how many psychiatrists practice their trade in Pakistan or Bangladesh, or how many citizens of both countries avail themselves of the various anti-depressants marketed by pharmaceutical concerns, including Prozac, Zoloft and Paxil.
GlaxoSmithKline (nyse: GSK - news - people ) already announced a similar effort to put up a clinical trial registry, after New York State Attorney General Eliot Spitzer filed a lawsuit relating to unpublished data on Glaxo's antidepressant Paxil.
"This victory is a strong confirmation of what we have been arguing since 1998: Our generic version of Paxil does not infringe any valid patents and therefore should be available to consumers today, " said Apotex Chief Executive Barry Sherman in a prepared statement.
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