Biarritz finished on a high as Yachvili broke away, linked with replacement Laurent Tranier and took the final pass to score.
The Bulls regained the lead on 54 minutes when replacement winger Tupou took Newton's pass to score his first try of the season.
Any hope of an unlikely Blues comeback was soon shattered when De Luca intercepted prop Rhys Gill's lazy pass to score a second try under the posts.
Dragons prop Thomas was shown a yellow card after 45 minutes for his team's persistent infringements and five minutes later Argentina wing Borges raced onto Robert Barbieri's pass to score.
Rob Burrow took over kicking duties from Sinfield but missed the conversion, although he was on target soon after to add the extras when Senior ran onto Pryce's pass to score.
Leeds extended their tenuous half-time lead four minutes into the second half when a barnstorming run from centre Keith Senior opened up the Warrington defence for Webb to take a return pass and score.
With little left to give, Leeds then gifted Wilkin his first score when he intercepted Sinfield's pass to run 30m to score under the posts.
He slipped a neat inside pass for Sackey to score under the posts and Walder's conversion brought Wasps back to within a point at half-time.
Although a Tickle penalty put the visitors in front, Leeds regained the lead when Donald collected Webb's long pass for his second score of the evening.
Then Habana sealed victory with another runaway after intercepting a pass by Hernandez to score his eighth try of the tournament, matching the record set by New Zealand's Jonah Lomu in 1999.
D'Arcy made the score with a neat step and offload and Kearney raced onto the pass to outpace the Ulster cover and score with Berne's conversion making it 10-3 at half-time.
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Richards took a long pass to cut inside and score the first before Roberts outpaced the Warrington defence and collected a clever kick from halfway by Sean O'Loughlin to race in.
It was all going the Rhinos' way, and a long Webb pass gave Donald the space to score his 13th try of the season.
The Giants started the second half with a flurry with Cudjoe starting the rout and finishing with a second-half hat-trick, saving the best for last with a length of the field score after an errant pass by Cameron Phelps.
Goulding scored either side of the break before Wakefield finally found some joy when Blanch intercepted a pass to race 80-metres to score.
The first came when James Roby's neat short pass set up prop James Graham to score, and then Wellens weighed in with his brace.
Webb added another score after taking the scoring pass from Donald before Solomona's brilliant diagonal kick gave Tadulala his second try on a plate.
The Ospreys kept pushing forward and replacement Gareth Owen touched down in the corner after a dazzling Williams break, only for referee Rolland to overrule the score for an earlier forward pass.
The Warrington man took a well-deserved rest but the scoring continued, with Wilkin crashing over from close range and McGuire taking advantage of a slick pass from Sinfield to touch down before providing the pass for full-back Wellens to score England's 10th try.
Lamb created the next try five minutes later, intercepting a Wallace pass and surging forward before his pass sent Simpson-Daniel rushing through to score.
The see-saw scoring continued after half-time, with James dummying the Connacht midfield to score, after Jenkins' long pass had created the space for the centre to run into.
Dan Tuohy crossed the Scarlets' line as the visitors made a quick riposte, but the flanker had overrun Nigel Brady in the build-up and the score was disallowed for a forward pass.
Many spectators were probably not even back in their seats after the interval when Ian Kirke failed to hold Matt Diskin's pass and Bentley was quickest to capitalise and score for the Dragons.
Castleford refused to lie down and produced a good contender for try of the weekend when fullback Jason Flowers finished a powerful 50m break with a delicate back pass to send Andrew Purcell over for the score.
And, two minutes later, Warrington cashed in with their sixth try when a Briers kick was plucked out of the air by Hicks, who squeezed the pass out of the tackle for King to score in the corner.
Warrington made an encouraging start to the second half with Rob Parker hauled down just short of the line by Stephen Wild, but seconds later Jensen gathered Mark Gleeson's pass and went the length the pitch to score.
The visitors began bravely before Leon Pryce and Willie Talau combined to put Meli over in the left-hand corner, and six minutes later former Everton trainee Matty Smith collected a Jason Cayless pass to put Wilkin over for his opening score.
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