Coach Dan Bylsma plans to use Jokinen to center wingers Pascal Dupuis and Chris Kunitz.
James Neal had a goal and three assists, and Pascal Dupuis scored twice for Pittsburgh.
Pittsburgh forward Chris Kunitz snapped a shot at Nabokov that clattered off his linemate, Pascal Dupuis, and skipped past Nabokov.
Fleury made 32 saves and didn't get a chance to really relax until Pascal Dupuis' empty-net goal in the final minute.
Jarome Iginla and James Neal each scored twice, Crosby, Chris Kunitz and Pascal Dupuis added goals, and Tomas Vokoun made 30 saves.
Jarome Iginla tied it in the first, and Pascal Dupuis made it 2-2 in the second for Pittsburgh, which got 35 saves from Vokoun.
Malkin added a tying goal in the second, and Brandon Sutter and Pascal Dupuis provided the Penguins with a pair of one-goal leads they couldn't protect.
"We needed two goals to win, one in regular time and one in the shootout, and he got both of those, " Pittsburgh forward Pascal Dupuis said.
Pascal Dupuis scored twice, Marc-Andre Fleury made 26 saves, and the top-seeded Penguins opened the playoffs with a 5-0 romp over the New York Islanders on Wednesday night.
The smile grew wider seconds later, when the Penguins won the ensuing faceoff, and Pascal Dupuis' crossing pass gave Crosby a wide-open net for the goal at 12:06.
Pascal Dupuis scored in the second period for the Penguins, who lost for the second consecutive night after 15 consecutive victories, two shy of tying the NHL record for longest winning streak.
Pascal Dupuis scored twice, Marc-Andre Fleury tied a franchise record with his sixth career shutout and the Penguins showed few weaknesses in their quest to bookend the Stanley Cup they won in 2009.
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