"It seems to work in the mouse models, and rather surprisingly it seems to work when orally administered, " says Alan Tall of Columbia University.

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Leopoldville engages in an all-out fight against infantile paralysis, crowding every clinic with mothers and their children, the latter to receive orally administered shots of a new vaccine against the scourge of childhood.

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Bristol-Myers and Aventis also are working separately on taxanes that can be administered orally, instead of in hour-long intravenous doses.

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Cullins stressed that Planned Parenthood will continue to offer medical abortion, but that the misoprostol will be administered orally.

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For one thing, the most advanced candidates in the pipeline are biologics, compounds that are not administered orally but instead by injection twice a month.

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Salk's vaccine, developed in the 1950s, involved injecting a virus that was "killed, " while Sabin's vaccine -- which he worked on in the 1960s and which was administered orally -- contained a weakened version of polio.

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And in those four cases, the second drug in the two-drug regimen was administered vaginally rather than orally.

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