It used to be, not very long ago, that you needed to hire an illustrator or designer to help you create one of these files or images.
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Finished results are easily accessed in Adobe Illustrator or Photoshop.
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Inkling can store thousands of sketches and export layered files directly to Adobe Photoshop and Illustrator (CS3 or newer), as well as Autodesk Sketchbook Pro (2011).
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Once I have a hi-res digital copy, I add in the text using Adobe Illustrator and export the final version to jpeg (for web) or TIFF (for print).
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