In normal times David Cameron's criticism of Labour's economic record would have had to include some scathing personal criticism or devastating new statistics for it to get any coverage beyond a nib (news in brief).
They could include, in no particular order of probability or potentially devastating impact on the stability of financial market, default by Greece, exit by Greece from the eurozone or a much more generous rescue deal.
Whether your business is an unprecedented success or a devastating failure, your time with it is limited to, at most, your own life span.
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You may not be in as heated a crucible or as devastating a trust void as Armstrong, and therefore the importance of trust may not seem as obvious.
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When it comes time to tell a child he or she has cancer, or some other devastating disease, many parents try to skirt the issue.
Yet while flood events may not be increasing in frequency or intensity, devastating consequences will predictably become worse so long as urban development continues to expand into flood plains.
Our current income tax laws create a hurdle to getting married or cause a devastating surprise when the newly married couple files their first tax return as husband and wife.
With massive debt and no savings, a financial crisis, whether personal or national, becomes devastating.
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She is a modern day heroine, who took highly constructive, courageous action to save countless other women from her fate rather than becoming bitter or debilitated by a devastating late breast cancer diagnosis and grueling treatment regimen.
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Now into this gloom comes a new type of drug, called an anti-CD3 antibody, that aims for the first time to delay or prevent development of the devastating disease by arresting the immune system's attack on pancreatic islet cells.
For such firms, the introduction of carbon taxes or fees on emissions could prove devastating.
Many viruses are harmless in their regular hosts (and therefore difficult or impossible to detect) but devastating if they switch to a new one.
In a multibillion-dollar gamble, some of the world's biggest drug companies have begun final-stage trials of drugs that aim to slow or halt the progression of the devastating dementia.
Most women who survived high school have likely experienced RA in one form or another, and you know how devastating it can be.
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In the U.S., deaths from hurricanes have been slashed drastically due to early warning systems and evacuation procedures, but in poor countries the effects can be devastating, leading to hundreds or thousands of deaths.
They will take on the short-term costs of raising their homes or the long-term risk of another devastating storm.
At the age of 34 and with a myriad of interests outside the ring, speculation has been swirling whether or not Pacquiao would continue fighting after his devastating knockout by the right fist of Juan Manuel Marquez in December.
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The hypothesis holds that these so-called amyloid plaques are a culprit in the disease's devastating symptoms, and that removing them or preventing growth could stymie Alzheimer's.
It makes no sense to me as a doctor seeing the same considerable needs from the same devastating illnesses costing a person either nothing or their whole life savings.
It was these economic consequences, from the costs of cleaning up to longer-term damage to business, running together into tens or hundreds of billions of dollars, that proved devastating.
Analysts have long wondered how those nations would ever be able to downsize or diversify their U.S. bond holdings without devastating markets.
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Strategic growth is now subject to potentially devastating government enforcement, which can either trigger or be triggered by related shareholder or public interest group legal actions.
The infections are nonetheless reviving fears among the public of an epidemic a decade after a devastating outbreak of severe acute respiratory syndrome, or SARS, which crippled tourism in China and Hong Kong.
"Having been through bullying myself I know just how devastating an effect it can have on any child or teenager, " he said.
China on Tuesday marked the first anniversary of a devastating earthquake that left nearly 90, 000 dead or missing one year ago in mountainous Sichuan province.
If we put all of our eggs into one or two baskets, a hole in one of those baskets could have devastating consequences.
The reality can be devastating for families with children taken into care for being obese, or suffering long-term health problems.
The result of this can be financially devastating: either because a painting proves to be a fake, or because a real painting, absent authentication, can be unsaleable.
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That would have devastating consequences on consumer spending and push the recovery out to late 2010 or 2011.
If we don't take corrective action, cyber attacks in the future could be as devastating as the "man-caused disaster" of an EMP attack or the naturally occurring variant.
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