According to Emanuel, tailoring medical treatments to individual characteristics of each patient is both overly optimistic and cost-prohibitive.
Prabhat Dayal, the chief of the Rajasthan Energy Development Agency, is optimistic about bringing down the cost of solar-generated electricity.
Yet he's optimistic about the long-term cost savings and synergies of the combined operation.
"Although challenges to worldwide PC demand remain, such as the pace of global economic recovery and the on-going debt crisis in Western Europe, and even a hard disk drive supply shortage and cost increase, Lenovo remains optimistic that its growth momentum will continue, " it said in a statement.
But it said it was still concerned that future budget assumptions were "over-optimistic" and that risks - such as the cost of bringing back equipment from Afghanistan - had not been fully factored into calculations.
Last year Novelis failed to cover its cost of capital, though Mr Birla is optimistic.
For example, experience with public-private partnerships shows that cost-benefit estimates can sometimes prove wildly optimistic.
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Despite the estimated cost savings, IDC's Griliches is optimistic about the router but warns that its performance is still untested.
By the same token, renewable technologies are following similar output efficiency and cost reduction curves, while growing more quickly than most optimistic projections of just a few years ago.
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Professor Alex Kemp, a petroleum economics expert at the University of Aberdeen, described the Falklands oil reserve estimates as "optimistic, " adding that even if they are proven, the cost of exploiting them could still be prohibitive.
That means it had to be much more efficient, lower cost, high volume, and well regarded than even its most optimistic backers probably expected.
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Even as the integration process is proceeding well, we expect temporary business impact from this large-scale merger but we are optimistic that the second half of 2013 will see more revenue growth momentum and cost synergies.
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Some may disagree with me on my basic assumptions, either viewing them as over optimistic or over pessimistic, but I think a discussion centered on growth, profitability and the cost of growth is not only a healthy one but one that we should be having about all young, growth companies.
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