Until now, one of the biggest problems with Enbrel was making enough of it.
One of the biggest problems was many people were diagnosed too late, it found.
"One of the biggest problems we are facing is stalled automobiles, " Mr. Malloy said.
One of the biggest problems in business development, partnerships, and sales is managing your pipeline.
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One of the biggest problems for News Corporation's film- and television-production business is digital piracy.
Medicaid's rising cost has become one of the biggest problems for states struggling to balance their budgets.
One of the biggest problems was that the tables were tilted against ordinary people in the financial system.
One of the biggest problems in the first two movies is the complete lack of compelling female characters.
It seems one of the biggest problems is that many Americans are still struggling with basic money management.
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Clocks are one of the biggest problems when daylight saving time kicks in.
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However, one of the biggest problems remains identifying people who have been infected.
One of the biggest problems we have with alternative energy is not just producing the energy, but also distributing it.
Obtaining access to capital to grow their businesses is one of the biggest problems faced by SMEs in China today.
One of the biggest problems with smart TVs in the last few years has been the sheer number of different platforms.
One of the biggest problems with corruption, whether in Russia or elsewhere, is that it makes market competition in next to impossible.
One of the biggest problems for the interim government remains the lack of aid, especially for mundane but essential tasks like policing.
One of the biggest problems Joplin residents continue to face is housing.
One of the biggest problems with online privacy is that much of the data collection and trading has, until now, been fairly opaque.
One of the biggest problems with history-based recommendation engines, particularly for broad product category e-commerce sites, is that they leverage the wrong signal.
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"It is one of the biggest problems affecting our clients, " says Benjamin Tobias, president of Tobias Financial Advisors, a wealth-management firm in Plantation, Fla.
One of the biggest problems is which "locating system" to use.
Assuming both the process and the conventions will be the same as they are at home is one of the biggest problems foreign buyers run into, Payne says.
One of the biggest problems, Mr. Hudson says, is that Congress exempted airlines from state laws so consumers can only take disputes to federal court, not state court.
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One of the biggest problems with higher premiums is that they often end up penalizing the people who are least able to afford insurance or meet wellness-program requirements.
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One of the biggest problems is that big cities are often split off from some of their suburbs, resulting in a higher GDP count for a lower population.
"It takes months sometimes to compile the information, because one of the biggest problems in the affected areas is the lack of precision and uncertainty at the scene, " Rosende said.
One of the biggest problems is "skimming" - when the magnetic strip is copied and the information used to clone a card that can then be used anywhere in the world.
Their goal was to have rotigotine delivered via a patch, since one of the biggest problems plaguing PD patients is keeping the right amount of medication in their systems throughout the day.
One of the biggest problems, Schnierer and Berchem agree, is that former hiring managers are often unwilling to disclose the reason for a past employee's termination, creating holes in a background check.
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