His job will be to make sure that authorities no longer allow banking troubles to build up over the years and only intervene in national lenders once it's too late.

WSJ: Economics Guru Jumps

However, amyloid may be only one factor in Alzheimer's, and growing evidence shows that plaques form relatively late in the disease process, leading some scientists to think that attacking amyloid once the clumps have already formed is too late.

WSJ: For Alzheimer's, a Fork in the Road

Yet once you do become incapacitated, it is generally too late legally to make changes in your estate planning documents.

FORBES: Sign A Healthcare Proxy, Living Will And Power Of Attorney

By American standards, the shareholders of Russian firms tend to find out what is wrong when it is too late, and have little redress once they do.

ECONOMIST: Russian shares

At some point, the rinse-repeat methodology renders an idea or company behind the curve, and once that's recognized, it's likely too late to alter one's tactics.

ENGADGET: Dreams, curiosity and a passion for what's next: picking the brain of Innovation Lab's Mads Thimmer

Once a city has sold its soul to the car, it is probably too late to get it back.

ECONOMIST: Urban sprawl

Hyundai Motor was once part of the giant Hyundai chaebol that crumbled after trying to grow too fast in the late 1980s and early 1990s.

FORBES: Magazine Article

Once you become an adult and you realize that's not true, it's too late.

NPR: Excerpt: 'The Elegance Of The Hedgehog'